Product Information
| MW (kDa) | 18 |
| Purity | A greater than or equal to 95% purity was determined by SDS-PAGE. |
| Endotoxin | Endotoxin levels are less than or equal to 1 EU / 1 μg hIL-1α. |
| Activity | The bioactivity of recombinant hIL-1α was determined in a D10S cell proliferation assay. The ED50 of each lot is less than or equal to 50 pg/ml. |
Recombinant human IL-1α was expressed in E. coli and is supplied in a lyophilized form.
Interleukin 1 alpha (IL-1α) belongs to the IL-1 family of cytokines with 11 members including IL-1β. IL-1α is expressed in many cell types of both hematopoietic and non-hematopoietic origins under steady state, and its expression can be increased in response to appropriate stimuli (1,2). Like IL-1β, IL-1α is also synthesized as a precursor (pro-IL-1α) and can be cleaved into smaller mature forms. However, both pro-IL-1α and the cleaved form of IL-1α are biologically active and can activate the signaling pathway through the membrane receptor IL-1R1. IL-1α is active both as a secreted form and as a membrane-bound form. Due to such characteristics, passive leakage of IL-1α from dying cells can activate inflammation, leading some researchers to consider IL-1α as a key “alarmin in the cell” that alerts the host to damage or injury (3,4). In addition, IL-1α can also enter the nucleus to modulate transcription (5,6).
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| Cat. # | Size | Qty. | Price |
|---|---|---|---|
| 62643S | 10 µg |
|
$ 238 |
PhosphoSitePlus®