19.9
#Q80XI9, #Q14623
16147, 3549
Background
Indian hedgehog (Ihh) is a cell signaling protein that is one of the three proteins in the hedgehog family (1-3). Ihh is expressed in adult kidney and liver and acts as an antagonist of the Wnt signaling pathway in colon cancers (1,2). The Wnt signaling pathway plays a role in carcinogenesis and in embryonic development, and any gene mutations in this pathway lead to various diseases (2,4-6). The Ihh protein is involved in chondrocyte differentiation, proliferation, and maturation especially during endochondral ossification, and is a regulator of bone growth (7).
- Marigo, V. et al. (1995) Genomics 28, 44-51.
- van den Brink, G.R. et al. (2004) Nat Genet 36, 277-82.
- Kumar, S. et al. (1996) Genetics 142, 965-72.
- Nusse, R. and Varmus, H.E. (1992) Cell 69, 1073-87.
- Logan, C.Y. and Nusse, R. (2004) Annu Rev Cell Dev Biol 20, 781-810.
- Komiya, Y. and Habas, R. (2008) Organogenesis 4, 68-75.
- Vortkamp, A. et al. (1996) Science 273, 613-22.
Endotoxin
Endotoxin levels are less than or equal to 1 EU / 1 μg h/mIhh.
Purity
A greater than or equal to 95% purity was determined by SDS-PAGE.
Source / Purification
Recombinant human/mouse Ihh was expressed in E. coli and is supplied in a lyophilized form.
Background
Indian hedgehog (Ihh) is a cell signaling protein that is one of the three proteins in the hedgehog family (1-3). Ihh is expressed in adult kidney and liver and acts as an antagonist of the Wnt signaling pathway in colon cancers (1,2). The Wnt signaling pathway plays a role in carcinogenesis and in embryonic development, and any gene mutations in this pathway lead to various diseases (2,4-6). The Ihh protein is involved in chondrocyte differentiation, proliferation, and maturation especially during endochondral ossification, and is a regulator of bone growth (7).
Background References
Cross-Reactivity Key
H: human M: mouse R: rat Hm: hamster Mk: monkey Vir: virus Mi: mink C: chicken Dm: D. melanogaster X: Xenopus Z: zebrafish B: bovine Dg: dog Pg: pig Sc: S. cerevisiae Ce: C. elegans Hr: horse GP: Guinea Pig Rab: rabbit All: all species expected
Trademarks and Patents
Limited Uses
Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.
Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.