# | Product Name | Applications | Reactivity | |
---|---|---|---|---|
5237 | Human Neurotrophin-3 (hNT-3) |
|
Product Information
The working concentration for NT-3 generally ranges from 50-100 ng/ml.
MW (kDa) | 30 |
Purity | >95% |
E. coli
Neurotrophins are comprised of at least four family members including NGF, BDNF, NT-3 and NT-4 and all are known to influence growth, development, differentiation and survival of neurons (1). Proneurotrophins bind to p75NTR but not to the family of Trk receptor tyrosine kinases (Trk). Following maturation, NT-3 binds and activates TrkA, TrkB and TrkC, with TrkC almost exclusively binding to NT-3. Mature NT-4 binds to and activates TrkB (2). Trk receptors in turn activate three major signaling pathways: (a) Ras/MAPK, which promotes neuronal differentiation and neurite outgrowth, (b) PI3 Kinase/Akt, which promotes survival and growth of neurons, and (c) PLC-γ 1/PKC, which promotes synaptic plasticity (2).
NT-3 knock-out mice display movement and posture deficiencies due to proprioception defects as well as loss of neurons in spinal and cephalic sensory ganglia (3-4).
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