Product Information
CST recommends using 50-100 ng/ml of IL-11 for stimulation of IL-11 signaling.
| MW (kDa) | 19.1 |
| Purity | >98% |
Human recombinant protein
Interleukin-11 (IL-11) was initially cloned as a mediator of plasmacytoma cell proliferation and was later found to exhibit a wide variety of biological effects in neural cells as well as in the hematopoietic and immune systems (1). IL-11 belongs to the interleukin-6 (IL-6)-type subfamily of long-chain helical cytokines including IL-6, ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M and cardiotrophin-1, which all share the glycoprotein gp130 as a signal transducing receptor component. IL-11 acts on cells expressing gp130 and the IL-11 receptor (IL-11R) α subunit. Both receptor subunits belong to the family of class I cytokine receptors. The complex of IL-11 and IL-11R triggers the activation of gp130 most likely by enforcing gp130 homodimerization (2). As a consequence of gp130 activation several cytoplasmic signal transduction cascades are initiated from which the Janus kinase (Jak)/signal transducer and activator of transcription (Stat) pathway has attracted considerable attention. Initiation of the Jak/Stat pathway in response to IL-11 requires Jak1 and leads predominantly to the activation of Stat3 (3,4).
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