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1022
HER4/ErbB4 Blocking Peptide
Experimental Controls
Blocking Peptide

HER4/ErbB4 Blocking Peptide #1022

Citations (0)
Immunohistochemical analysis of paraffin-embedded human prostate carcinoma, using HER4/ErbB4 (83B10) Rabbit mAb (IHC Specific) #4792 in the presence of control peptide (left) or HER4/ErbB4 Blocking Peptide (right).

Product Usage Information

For Immunohistochemistry, add twice the volume of peptide as volume of antibody used in 100 μl total volume. Incubate for a minimum of 30 minutes prior to adding the entire volume to the slide. Recommended antibody dilution can be found on the HER4/ErbB4 (83B10) Rabbit mAb (IHC Specific) #4792 data sheet.

Storage

Supplied in 20 mM potassium phosphate (pH 7.0), 50 mM NaCl, 0.1 mM EDTA, 1 mg/ml BSA and 5% glycerol. Store at –20°C.

Product Description

This peptide is used to block HER4/ErbB4 (83B10) Rabbit mAb (IHC specific) #4792 reactivity.

Quality Control

The quality of the peptide was evaluated by reverse-phase HPLC and by mass spectrometry. The peptide blocks HER4/ErbB4 (83B10) Rabbit mAb (IHC specific) Ab #4792 signal in immunohistochemistry.

Background

Research studies have implicated the HER/ErbB receptor tyrosine kinase family in normal development, cardiac function and cancer (1,2). HER4/ErbB4, like other family members, has four ectodomains, a single transmembrane domain and a cytoplasmic tail containing the active tyrosine kinase domain (3). By binding to neuregulins and/or EGF family ligands, ErbB4 forms either a homodimer or heterodimer with other ErbB family members, which results in receptor activation and signaling (3). ErbB4 is ubiquitously expressed with the highest expression occurring in brain and heart. The expression of ErbB4 in breast cancer, pediatric brain cancer and other types of carcinomas has been reported in research studies suggesting that ErbB4 expression is involved in both normal tissue development and carcinogenesis (3).

Pathways

Explore pathways related to this product.

Limited Uses

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For Research Use Only. Not for Use in Diagnostic Procedures.
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