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1525
IGF-I Receptor β Blocking Peptide
Experimental Controls

IGF-I Receptor β Blocking Peptide #1525

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Product Usage Information

Use as a blocking reagent to evaluate the specificity of antibody reactivity in dot blot protocol.

Storage:

Supplied in 20 mM potassium phosphate (pH 7.0), 50 mM NaCl, 0.1 mM EDTA, 1 mg/ml BSA, 5% glycerol and 1% DMSO. Store at –20°C.

Product Description

This peptide is used to block IGF-I Receptor β Antibody #3027 reactivity in dot blot protocols.

Quality Control

The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry. The peptide reacts with IGF-I Receptor β Antibody #3027 in dot blot.

Background

Insulin-like growth factor 1 (IGF-1) is a small (7.65 kDa) growth factor that interacts with both the IGF-1 receptor and the insulin receptor to control cell growth and apoptosis. Release of this endocrine hormone from the liver is stimulated by growth hormone produced in the anterior pituitary (1). Circulating IGF-1 is typically bound to one of six known IGF binding proteins (IGF-BP) (2). At target cells, the IGF-1 ligand binds IGF receptors (or insulin receptors) leading to receptor autophosphorylation and activation (3). Activated receptors mediate downstream signaling pathways (including Akt and MAPK) that regulate cell proliferation, apoptosis, development and longevity. Altered expression or mutation of IGF-1 is associated with several human disorders, including type I diabetes and various forms of cancer (4). Recombinant human IGF-1 has been used in clinical trials as a potential therapeutic agent in the treatment of human diseases (5).

  1. Le Roith, D. (1997) N Engl J Med 336, 633-40.
  2. Jones, J.I. and Clemmons, D.R. (1995) Endocr Rev 16, 3-34.
  3. Hernández-Sánchez, C. et al. (1995) J Biol Chem 270, 29176-81.
  4. Sandhu, M.S. (2005) Endocr Dev 9, 44-54.
  5. Trojan, J. et al. (2007) Neuroscience 145, 795-811.

Pathways & Proteins

Explore pathways + proteins related to this product.

For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

Important Ordering Details

Custom Ordering Details: This product is assembled upon order. Please allow up to three weeks for your product to be processed.