News from the Bench
Discover what’s going on at CST, receive our latest application notes and tips, read our science features, and learn about our products.
Important Ordering DetailsCustom Ordering Details: Sections are cut freshly upon ordering. Please allow up to three business days for your product to be processed.
the purchase of 3 or more products
To Purchase # 13747S
|13747S||1 Pack (5 slides)||$132.00.0|
Find answers on our FAQs page.
- Additional protein information
- Analytical tools
SignalSlide® PD-L1 IHC Controls #13747
Gallery: SignalSlide® PD-L1 IHC Controls #13747
- Immunohistochemical analysis of paraffin-embedded HDLM-2 (left) and PC3 (right) cell pellets using PD-L1 (E1L3NTM) XP® Rabbit mAb #13684.
Each control slide contains formalin fixed, paraffin-embedded cell pellets, HDLM-2 (PD-L1 positive) and PC-3 (PD-L1 negative), that serve as controls for PD-L1 immunostaining.
Programmed cell death 1 ligand 1 (PD-L1, B7-H1, CD274) is a member of the B7 family of cell surface ligands that regulate T cell activation and immune responses. The PD-L1 ligand binds the PD-1 transmembrane receptor and inhibits T cell activation. PD-L1 was discovered following a search for novel B7 protein homologs and was later shown to be expressed by antigen presenting cells, activated T cells, and tissues including placenta, heart, and lung (1-3). Similar in structure to related B7 family members, PD-L1 protein contains extracellular IgV and IgC domains and a short, cytoplasmic region. Research studies demonstrate that PD-L1 is expressed in several tumor types, including melanoma, ovary, colon, lung, breast, and renal cell carcinomas (4-6). Expression of PD-L1 in cancer is associated with tumor infiltrating lymphocytes, which mediate PD-L1 expression through the release of interferon gamma (7). Additional research links PD-L1 expression to cancers associated with viral infections (8,9).
For Research Use Only. Not For Use In Diagnostic Procedures. Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc. SignalSlide is a registered trademark of Cell Signaling Technology, Inc. XP is a registered trademark of Cell Signaling Technology, Inc.