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Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

mGluR2 recognizes endogenous levels of total mGluR2 protein. This antibody does not cross-react with mGluR3.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala839 of mouse mGluR2 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Metabotropic glutamate receptor 2 (mGluR2) is a class C G protein-coupled receptor for the neurotransmitter glutamate in the mammalian brain. Unlike ionotropic receptors, metabotropic receptors do not form an ion channel pore themselves but are indirectly linked to ion channels (1). While mGluR1 and mGluR5 activate phospholipase C, mGluR2, mGluR3, mGluR4, and mGluR6 are coupled to the inhibitory G protein Gα(i/o) and inhibit adenylyl cyclase (AC) activity (1). Research studies have suggested that mGluR2/3 receptors may be potential targets for the treatment of Schizophrenia (2). Furthermore, mGluR2 interacts with the 5HT2A serotonin receptor to form a hetero-complex in the brain. This complex is a potential pharmacological target for hallucinogenic drugs (3,4).

1.  Pin, J.P. et al. (1994) EMBO J 13, 342-8.

2.  Patil, S.T. et al. (2007) Nat Med 13, 1102-7.

3.  González-Maeso, J. et al. (2008) Nature 452, 93-7.

4.  González-Maeso, J. and Sealfon, S.C. (2009) Trends Neurosci 32, 225-32.

Entrez-Gene Id 108068
Swiss-Prot Acc. Q14BI2

For Research Use Only. Not For Use In Diagnostic Procedures.
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mGluR2 Antibody