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55 Rabbit

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

Sox17 recognizes endogenous levels of total Sox17 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro276 of human Sox17 protein. Antibodies are purified by protein A and peptide affinity chromatography.

SRY-related high mobility group box (SOX) proteins comprise a large family of widely conserved transcription factors that play important roles in development. SOX proteins possess a high mobility group (HMG) motif that binds the DNA minor groove. SOX proteins do not directly mediate transcription, but require binding partners that regulate their ability to mediate transcription of target genes that control cell fate determination and development (reviewed in 1).

Transcription factor Sox17 is a Sox family protein with an established role in endoderm specification during development (2). In addition, Sox17 plays essential roles in the maintenance of the hematopoietic stem cell pool (3) and for vascular morphogenesis during development (4,5). Sox17 negatively regulates oligodendrocyte precursor differentiation by antagonizing β-catenin signaling (6). Mutation in the corresponding Sox17 gene in humans is associated with a form of vesicoureteral reflux, a disorder characterized by congenital kidney and urinary tract defects (7).

1.  Kamachi, Y. and Kondoh, H. (2013) Development 140, 4129-44.

2.  Engert, S. et al. (2013) Development 140, 3128-38.

3.  Clarke, R.L. et al. (2013) Nat Cell Biol 15, 502-10.

4.  Lange, A.W. et al. (2014) Dev Biol 387, 109-20.

5.  Choi, E. et al. (2012) Stem Cells 30, 2297-308.

6.  Chew, L.J. et al. (2011) J Neurosci 31, 13921-35.

7.  Gimelli, S. et al. (2010) Hum Mutat 31, 1352-9.

Entrez-Gene Id 64321
Swiss-Prot Acc. Q9H6I2

For Research Use Only. Not For Use In Diagnostic Procedures.
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Sox17 Antibody