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CD8α (53-6.7) Rat mAb #13989
This product is discontinued
We recommend the following alternatives
| 70306 | CD8α (C8/144B) Mouse mAb (IHC Specific) |
|
H | |
| 85336 | CD8α (D8A8Y) Rabbit mAb | 
|
H | |
| 98941 | CD8α (D4W2Z) XP® Rabbit mAb (Mouse Specific) |
|
M | XP |
| REACTIVITY | SENSITIVITY | MW (kDa) | Isotype |
|---|---|---|---|
| Rat |
Product Usage Information
Specificity / Sensitivity
CD8α (53-6.7) Rat mAb recognizes endogenous levels of mouse CD8α protein by flow cytometry.
Source / Purification
Monoclonal antibody is produced by immunizing animals with mouse spleen cells.
Background
Cluster of Differentiation 8 (CD8) is a disulphide-linked heterodimer consisting of the unrelated α and β subunits. Each subunit is a glycoprotein composed of a single extracellular Ig-like domain, a polypeptide linker, a transmembrane part and a short cytoplasmic tail. On T cells, CD8 is the coreceptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen–Major Histocompatibility Complex (MHC). Specifically, the Ig-like domain of CD8α interacts with the α3-domain of the MHC class I molecule. CD8 ensures specificity of the TCR–antigen interaction, prolongs the contact between the T cell and the antigen presenting cell, and the α chain recruits the tyrosine kinase Lck, which is essential for T cell activation (1).
1. Zamoyska, R. (1994) Immunity 1, 243-46.
Data Sheets & Documentation
For Research Use Only. Not For Use In Diagnostic Procedures. Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
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