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60 Mouse 

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

Trf1 (BED5) Mouse mAb detects endogenous levels of total Trf1 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with recombinant human Trf1.

Telomeres, the linear ends of chromosomes, are organized into T-loops to prevent them from being recognized by the cell as DNA double stranded breaks (DSBs) (1). A large number of proteins, including telomeric repeat binding factor proteins Trf1 and Trf2, are bound to the telomeres forming a complex of proteins known as shelterin or the telosome (2). Both Trf1 and Trf2 are known to regulate telomere length, participate in the DNA damage response, and contribute to chromosome stability (3-5).

1.  Colgin, L. and Reddel, R. (2004) Curr Biol 14, R901-2.

2.  Xin, H. et al. (2008) Genome Biol 9, 232.

3.  Benetti, R. et al. (2008) Cell Cycle 7, 3461-8.

4.  Okamoto, K. et al. (2008) J Biol Chem 283, 23981-8.

5.  Stagno D'Alcontres, M. et al. (2007) J Cell Biol 179, 855-67.

Entrez-Gene Id 7013
Swiss-Prot Acc. P54274

For Research Use Only. Not For Use In Diagnostic Procedures.
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Trf1 (BED5) Mouse mAb