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Dec 31st Santa Cruz will discontinue a
large number of polyclonal products as
a result of the USDA settlement that was
made public May 19th.

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We recommend the following alternatives

W IP   IF     H M R
REACTIVITY SENSITIVITY MW (kDa) SOURCE
21 to 22 Rabbit

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

Max Antibody detects endogenous levels of total Max protein.


Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues around Tyr115 of human Max. Antibodies are purified by protein A and peptide affinity chromatography.

Members of the Myc/Max/Mad network function as transcriptional regulators with roles in various aspects of cell behavior including proliferation, differentiation and apoptosis (1). These proteins share a common basic-helix-loop-helix leucine zipper (bHLH-ZIP) motif required for dimerization and DNA-binding. Max was originally discovered based on its ability to associate with c-Myc and found to be required for the ability of Myc to bind DNA and activate transcription (2). Subsequently, Max has been viewed as a central component of the transcriptional network, forming homodimers as well as heterodimers with other members of the Myc and Mad families (1). The association between Max and either Myc or Mad can have opposing effects on transcriptional regulation and cell behavior (1). The Mad family consists of four related proteins; Mad1, Mad2 (Mxi1), Mad3 and Mad4, and the more distantly related members of the bHLH-ZIP family, Mnt and Mga. Like Myc, the Mad proteins are tightly regulated with short half-lives. In general, Mad family members interfere with Myc-mediated processes such as proliferation, transformation and prevention of apoptosis by inhibiting transcription (3,4).


1.  Baudino, T.A. and Cleveland, J.L. (2001) Mol Cell Biol 21, 691-702.

2.  Blackwood, E.M. and Eisenman, R.N. (1991) Science 251, 1211-7.

3.  Henriksson, M. and Lüscher, B. (1996) Adv Cancer Res 68, 109-82.

4.  Grandori, C. et al. (2000) Annu Rev Cell Dev Biol 16, 653-99.


Entrez-Gene Id 4149
Swiss-Prot Acc. P61244


For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

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Max Antibody