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49, 75 Rabbit

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

ASCT2 (G11) Antibody detects endogenous levels of total ASCT2 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human ASCT2 protein. Antibodies were purified by protein A and peptide affinity chromatography.

Sodium-dependent neutral amino acid transporter type 2 (ASCT2 or SLC1A5) is a neutral amino acid transporter that regulates the uptake of essential amino acids in conjunction with the SLC7A5 bilateral transporter (1,2). ASCT2 appears to be the major glutamine transporter in hepatoma cells and is thought to provide essential amino acids needed for tumor growth (3). Additional evidence suggests that ASCT2 plays a role in activating mTORC1 signaling and is required to suppress autophagy (4,5). Cell surface ASCT2 serves as a receptor for several mammalian interference retroviruses associated with cases of infectious immunodeficiency; variation in a small region of an extracellular loop (ECL2) may be responsible for species-specific differences in receptor function (6).

1.  Utsunomiya-Tate, N. et al. (1996) J Biol Chem 271, 14883-90.

2.  Bröer, S. (2008) Physiol Rev 88, 249-86.

3.  Bode, B.P. et al. (2002) Am J Physiol Gastrointest Liver Physiol 283, G1062-73.

4.  Fuchs, B.C. et al. (2007) Am J Physiol Cell Physiol 293, C55-63.

5.  Nicklin, P. et al. (2009) Cell 136, 521-34.

6.  Marin, M. et al. (2003) J Virol 77, 2936-45.

Entrez-Gene Id 6510
Swiss-Prot Acc. Q15758

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

ASCT2 (G11) Antibody