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8096
CASK (D14E3) Rabbit mAb

CASK (D14E3) Rabbit mAb #8096

This product is discontinued

Storage:

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

CASK (D14E3) Rabbit mAb recognizes endogenous levels of total CASK protein. This antibody also detects a background band of unknown origin at 75 kDa.

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly233 of human CASK protein.

CASK is an adaptor protein with a calcium/calmodulin-dependent protein kinase domain, an SH3 domain, a guanylate kinase homology domain (GUK), and a PDZ domain. CASK links transmembrane proteins to the cytoskeleton and signaling molecules. In particular, CASK binds to neurexin to stabilize pre- and post-synaptic structures (1). While most CASK protein (~80%) is cytoplasmic, a portion of the protein enters the nucleus, where it acts as a transcriptional coactivator (2). Transgenic mice with CASK insertional mutations die within 24 hours of birth (3).

  1. Hata, Y. et al. (1996) J Neurosci 16, 2488-94.
  2. Hsueh, Y.P. et al. (2000) Nature 404, 298-302.
  3. Laverty, H.G. and Wilson, J.B. (1998) Genomics 53, 29-41.
Entrez-Gene Id
8573
Swiss-Prot Acc.
O14936
For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

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