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8474
Munc18-1 Antibody

Munc18-1 Antibody #8474

This product is discontinued

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Storage:

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Munc18-1 Antibody recognizes endogenous levels of total Munc18-1 protein.

Species predicted to react based on 100% sequence homology:

Monkey

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near Asp453 of human Munc18-1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Munc18-1 belongs to the Munc18 protein family that also includes Munc18-2 and Munc18-3. These proteins are highly conserved at the amino acid sequence level and play a critical role in membrane fusion. Munc18 proteins control SNARE complex formation (1,2) and interact with syntaxin (3). In Munc18-1 knockout mice, neurotransmitter release is completely abolished (4). In addition, Munc18-1 acts as a molecular chaperone for syntaxin-1, allowing for formation of the SNARE complex at the plasma membrane (5). Munc18-1 also acts as a regulator of vesicle docking during exocytosis (6).

  1. Rizo, J. and Südhof, T.C. (2002) Nat Rev Neurosci 3, 641-53.
  2. Südhof, T.C. and Rothman, J.E. (2009) Science 323, 474-7.
  3. Han, G.A. et al. (2010) J Neurochem 115, 1-10.
  4. Verhage, M. et al. (2000) Science 287, 864-9.
  5. Medine, C.N. et al. (2007) J Cell Sci 120, 4407-15.
  6. Voets, T. et al. (2001) Neuron 31, 581-91.
Entrez-Gene Id
6812
Swiss-Prot Acc.
P61764
For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

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