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Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

Munc18-1 Antibody recognizes endogenous levels of total Munc18-1 protein.

Species predicted to react based on 100% sequence homology: Monkey

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near Asp453 of human Munc18-1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Munc18-1 belongs to the Munc18 protein family that also includes Munc18-2 and Munc18-3. These proteins are highly conserved at the amino acid sequence level and play a critical role in membrane fusion. Munc18 proteins control SNARE complex formation (1,2) and interact with syntaxin (3). In Munc18-1 knockout mice, neurotransmitter release is completely abolished (4). In addition, Munc18-1 acts as a molecular chaperone for syntaxin-1, allowing for formation of the SNARE complex at the plasma membrane (5). Munc18-1 also acts as a regulator of vesicle docking during exocytosis (6).

1.  Rizo, J. and Südhof, T.C. (2002) Nat Rev Neurosci 3, 641-53.

2.  Südhof, T.C. and Rothman, J.E. (2009) Science 323, 474-7.

3.  Han, G.A. et al. (2010) J Neurochem 115, 1-10.

4.  Verhage, M. et al. (2000) Science 287, 864-9.

5.  Medine, C.N. et al. (2007) J Cell Sci 120, 4407-15.

6.  Voets, T. et al. (2001) Neuron 31, 581-91.

Entrez-Gene Id 6812
Swiss-Prot Acc. P61764

For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

Munc18-1 Antibody