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8549
ADRM1 Antibody

ADRM1 Antibody #8549

This product is discontinued

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H M R Mk
Storage:

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

ADRM1 Antibody recognizes endogenous levels of total ADRM1 protein.

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human ADRM1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Currently, there are five ubiquitin receptors associated with the proteasome: two proteasome subunits, Rpn10/S5a/PSMD4 and Rpn13/ADRM1 (Adhesion-regulating molecule 1), and three families of shuttling factors, Rad23, Dsk2, and Ddi1. ADRM1 is a ubiquitin receptor of the proteasome (1,2) that binds ubiquitin via a pleckstrin homology domain known as the pleckstrin-like receptor for ubiquitin (Pru) domain. The carboxy-terminal domain of mammalian ADRM1 serves to bind and enhance the isopeptidase activity of UCHL5/UCH37 (3-5), perhaps serving as a mechanism to accelerate ubiquitin chain disassembly. A murine Adrm1 knockout results in defective gametogenesis, thus highlighting a physiologic role for endogenous ADRM1 in mammalian development (6).

  1. Schreiner, P. et al. (2008) Nature 453, 548-52.
  2. Husnjak, K. et al. (2008) Nature 453, 481-8.
  3. Yao, T. et al. (2006) Nat Cell Biol 8, 994-1002.
  4. Hamazaki, J. et al. (2006) EMBO J 25, 4524-36.
  5. Qiu, X.B. et al. (2006) EMBO J 25, 5742-53.
  6. Al-Shami, A. et al. (2010) PLoS One 5, e13654.
Entrez-Gene Id
11047
Swiss-Prot Acc.
Q16186
For Research Use Only. Not For Use In Diagnostic Procedures.

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