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Rhodopsin Antibody #8710
This product is discontinued
Gallery: Rhodopsin Antibody #8710
Rhodopsin Antibody recognizes endogenous levels of total rhodopsin protein. This antibody may also detect rhodopsin protein at 55 kDa.Species predicted to react based on 100% sequence homology: Hamster, Monkey
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro7 of human rhodopsin protein. Antibodies are purified by protein A and peptide affinity chromatography.
Rhodopsin is the photoreceptor in the retinal rods. It is activated by photons, transduces visual information through its cognate G protein, transducin, and is inactivated by arrestin binding (1). Using atomic-force microscopy, rhodopsin was found to be arranged into paracrystalline arrays of dimers in mouse disc membranes (2). Rhodopsin is considered to be the prototype of G protein-coupled receptors (GPCRs), and is the first GPCR for which a crystal structure was solved (3). Research studies have linked mutations in the gene encoding rhodopsin to retinitis pigmentosa (4,5), a disease characterized by retinal degeneration resulting in reduced peripheral vision and night blindness (6).
For Research Use Only. Not For Use In Diagnostic Procedures. Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.