Buy 3 Get a 4th Free* | Learn More >>
8710
Rhodopsin Antibody

Rhodopsin Antibody #8710

This product is discontinued

We recommend the following alternatives

  • WB
  • IP
M R
  • IHC
  • IF
H M R
Storage:

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Rhodopsin Antibody recognizes endogenous levels of total rhodopsin protein. This antibody may also detect rhodopsin protein at 55 kDa.

Species predicted to react based on 100% sequence homology:

Hamster, Monkey

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro7 of human rhodopsin protein. Antibodies are purified by protein A and peptide affinity chromatography.

Rhodopsin is the photoreceptor in the retinal rods. It is activated by photons, transduces visual information through its cognate G protein, transducin, and is inactivated by arrestin binding (1). Using atomic-force microscopy, rhodopsin was found to be arranged into paracrystalline arrays of dimers in mouse disc membranes (2). Rhodopsin is considered to be the prototype of G protein-coupled receptors (GPCRs), and is the first GPCR for which a crystal structure was solved (3). Research studies have linked mutations in the gene encoding rhodopsin to retinitis pigmentosa (4,5), a disease characterized by retinal degeneration resulting in reduced peripheral vision and night blindness (6).

  1. Arshavsky, V.Y. and Burns, M.E. (2012) J Biol Chem 287, 1620-6.
  2. Fotiadis, D. et al. (2003) Nature 421, 127-8.
  3. Palczewski, K. et al. (2000) Science 289, 739-45.
  4. Rivolta, C. et al. (2002) Hum Mol Genet 11, 1219-27.
  5. Wilson, J.H. and Wensel, T.G. (2003) Mol Neurobiol 28, 149-58.
  6. Hartong, D.T. et al. (2006) Lancet 368, 1795-809.
Entrez-Gene Id
6010
Swiss-Prot Acc.
P08100
For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

Upstream / Downstream

pathwayImage

Explore pathways related to this product.