Upstream / Downstream
Explore pathways related to this product.
Our U.S. Offices Are Closed
Our U.S. offices are closed in observance of Memorial Day. We will reopen on Tuesday, May 30th.
Thank you for your patience.
Find answers on our FAQs page.
- Additional protein information
- Analytical tools
Phospho-CREB (Ser133) Antibody #9191
This product is discontinued
Gallery: Phospho-CREB (Ser133) Antibody #9191
Phospho-CREB (Ser133) Antibody detects endogenous levels of CREB only when phosphorylated at serine 133. This antibody also detects the phosphorylated form of the CREB-related protein ATF-1, and has been shown to react weakly with overexpressed levels of pyruvate dehydrogenase.
Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser133 of human CREB. Antibodies are purified by protein A and peptide affinity chromatography.
CREB is a bZIP transcription factor that activates target genes through cAMP response elements. CREB is able to mediate signals from numerous physiological stimuli, resulting in regulation of a broad array of cellular responses. While CREB is expressed in numerous tissues, it plays a large regulatory role in the nervous system. CREB is believed to play a key role in promoting neuronal survival, precursor proliferation, neurite outgrowth, and neuronal differentiation in certain neuronal populations (1-3). Additionally, CREB signaling is involved in learning and memory in several organisms (4-6). CREB is able to selectively activate numerous downstream genes through interactions with different dimerization partners. CREB is activated by phosphorylation at Ser133 by various signaling pathways including Erk, Ca2+, and stress signaling. Some of the kinases involved in phosphorylating CREB at Ser133 are p90RSK, MSK, CaMKIV, and MAPKAPK-2 (7-9).
For Research Use Only. Not For Use In Diagnostic Procedures. Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.