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Langerin Antibody #9484
This product is discontinued
Gallery: Langerin Antibody #9484
Langerin Antibody recognizes endogenous levels of total langerin protein.Species predicted to react based on 100% sequence homology: Mouse
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala81 of mouse langerin protein. Antibodies are purified by protein A and peptide affinity chromatography.
Langerin (CD207) is a C-type lectin receptor whose expression is restricted mainly to dendritic cells in the skin including Langerhans cells in the epidermis and langerin+/CD103+ dermal dendritic cells (1-4). Langerin is found on the cell surface and within rod-shaped organelles called Birbeck granules, and its expression is required for the formation of Birbeck granules (1,5). Langerin recognizes carbohydrate motifs on the surface of pathogens, resulting in endocytosis of the pathogen into Birbeck granules, degradation of the pathogen, and antigen presentation to T cells (6-8).
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