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9589
Slug (L40C6) Mouse mAb

Slug (L40C6) Mouse mAb #9589

This product is discontinued

We recommend the following alternatives

  • WB
  • IP
  • IF
  • F
H M
Storage:

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Slug (L40C6) Mouse mAb detects endogenous levels of total Slug protein. It does not recognize transfected human or mouse Snail proteins.

Monoclonal antibody is produced by immunizing animals with a recombinant human Slug protein.

Slug (SNAI2) is a widely expressed transcriptional repressor and member of the Snail family of zinc finger transcription factors (1). Similar to the related Snail protein, Slug binds to the E-cadherin promoter region to repress transcription during development (2). The binding of Slug to integrin promoter sequences represses integrin expression and results in reduced cell adhesion (3). Down regulation of E-cadherin expression occurs during the epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells (4,5). The tumor suppressor protein p53 induces Slug expression in γ-irradiated cells; Slug protects damaged cells from apoptosis by repressing p53-induced transcription of the proapoptotic Bcl-2 family protein Puma (6). Deletion mutations in the corresponding Slug gene are associated with the pigmentation disorders Waardenburg Syndrome and Piebaldism, while a genetic duplication resulting in Slug overexpression is associated with a collection of congenital heart defects termed tetralogy of Fallot (7).

  1. Inukai, T. et al. (1999) Mol Cell 4, 343-52.
  2. Bolós, V. et al. (2003) J Cell Sci 116, 499-511.
  3. Turner, F.E. et al. (2006) J Biol Chem 281, 21321-31.
  4. Barrallo-Gimeno, A. and Nieto, M.A. (2005) Development 132, 3151-61.
  5. Castro Alves, C. et al. (2007) J Pathol 211, 507-15.
  6. Wu, W.S. et al. (2005) Cell 123, 641-53.
  7. Pérez-Mancera, P.A. et al. (2006) Cytogenet Genome Res 114, 24-9.
Entrez-Gene Id
6591
Swiss-Prot Acc.
O43623
For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

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