| # | Product Name | |||
|---|---|---|---|---|
| 9941 | Pro-Survival Bcl-2 Family Antibody Sampler Kit |
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| 9942 | Pro-Apoptosis Bcl-2 Family Antibody Sampler Kit |
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Product Information
Polyclonal antibodies are produced by immunizing animals with synthetic peptides corresponding to the residues surrounding Ser70 of human Bcl-2; Asp61 of human Bcl-xL; the amino-terminal residues of human Bax and Bak; and Ser112 of mouse Bad. Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the residues surrounding Ser112 of mouse Bad. Polyclonal antibodies are purified by protein A and peptide affinity chromatography.
Bcl-2 exerts a survival function in response to a wide range of apoptotic stimuli through inhibition of mitochondrial cytochrome c release (1). It has been implicated in modulating mitochondrial calcium homeostasis and proton flux (2). Several phosphorylation sites have been identified within Bcl-2, including Thr56, Ser70, Thr74, and Ser87 (3). It has been suggested that these phosphorylation sites may be targets of the ASK1/MKK7/JNK1 pathway and that phosphorylation of Bcl-2 may be a marker for mitotic events (4,5). Mutation of Bcl-2 at Thr56 or Ser87 inhibits its anti-apoptotic activity during glucocorticoid-induced apoptosis of T lymphocytes (6). Interleukin-3 and JNK-induced Bcl-2 phosphorylation at Ser70 may be required for its enhanced anti-apoptotic functions (7).
Description: The Bcl-2 Family Antibody Sampler Kit contains enough primary and secondary antibodies to perform four Western mini-blot experiments.
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