| Product Includes | Product # | Quantity | Mol. Wt | Isotype/Source |
|---|---|---|---|---|
| Basic FGF (E9S5A) Rabbit mAb | 98658 | 20 µl | 18, 22, 24 kDa | Rabbit IgG |
| IGF-I (E6B7O) Rabbit mAb | 73034 | 20 µl | 9, 13, 18, 20 kDa | Rabbit IgG |
| HGF β (D6S7D) XP® Rabbit mAb | 52445 | 20 µl | 35, 85 kDa | Rabbit IgG |
| TGF-β (56E4) Rabbit mAb | 3709 | 20 µl | 12, 45-60 kDa | Rabbit |
| HBEGF (E5L5T) Rabbit mAb | 27450 | 20 µl | 18, 21, 27 kDa | Rabbit IgG |
| MIF (E7T1W) Rabbit mAb | 87501 | 20 µl | 12 kDa | Rabbit IgG |
| EREG (D4O5I) Rabbit mAb | 12048 | 20 µl | 17,19, 30 kDa | Rabbit IgG |
| Angiopoietin-2 (D200) Antibody | 50697 | 20 µl | 68, 70 kDa | Rabbit |
| Anti-rabbit IgG, HRP-linked Antibody | 7074 | 100 µl | Goat | |
| VEGF-A (E9X8Q) Rabbit mAb | 50661 | 20 µl | 16, 20, 23, 26 kDa | Rabbit IgG |
Please visit cellsignal.com for individual component applications, species cross-reactivity, dilutions, protocols, and additional product information.
Description
The Cancer-associated Growth Factor Antibody Sampler Kit provides an economical means of detecting selected growth factors that have been shown to influence tumor development. The kit includes enough antibodies to perform two western blot experiments with each primary antibody.
Storage
Background
The tumor microenvironment (TME) is composed of a heterogenous mixture of tumor cells, blood vessels, fibroblasts, stromal cells, infiltrating immune cells, and extracellular matrix (ECM) components, whose collective interactions play important roles in tumor development (1). Cells in the TME secrete a variety of bioactive molecules, including growth factors, cytokines, ECM proteins, and proteases (e.g., MMPs), many of which play critical roles in regulating growth and development of the tumor (2,3). Growth factors play particularly important roles in the TME, serving as cellular messengers that trigger activation or suppression of signaling pathways that govern tumor development, either directly via the tumor cells, or indirectly by way of effects on the TME. Binding of growth factors to their cognate receptors leads to activation of intracellular signaling pathways, resulting in changes in the expression of target genes that regulate cell behavior. Many growth factors (e.g., IGFs, HGFs, FGFs, HBEGF, EREG) are known to promote tumor development by way of direct effects on tumor cells; other growth factors can affect tumor development indirectly, through effects in the TME that influence tumor angiogenesis (e.g., VEGFs, angiopoietins), ECM deposition (TGF-β), or immune cell signaling (e.g., TGF-β, HBEGF, MIF) (4). The diverse and complex role played by growth factors in promoting tumorigenesis makes them important therapeutic targets in oncology, while elucidating the functions of specific growth factors in the context of tumor development remains an active area of cancer research (5).
Background References
Trademarks and Patents
Limited Uses
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Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.
