FC-FP
H
Endogenous
100
Mouse IgG1
#P08473
4311
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Flow Cytometry (Fixed/Permeabilized) | 1:25 |
Storage
Specificity / Sensitivity
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing BALB/c mice with CALLA cells.
Background
CD10 (CALLA or neprilysin) was identified as a marker for leukemic cells in children with acute lymphoblastic leukemia and belongs to a family of exoenzymes that include aminopeptidase A, N and dipeptidylpeptidase IV (1-2). CD10 is a transmembrane type II molecule and functions as a metallo-peptidase requiring zinc. Specifically, CD10 cleaves 1-3 amino-terminal amino acids from peptides with a preference for neutral amino acids (valine, iso-leucine, phenylalanine, leucine or alanine) (2). The CD10 antigen is expressed by immature and by germinal center B cells, by granulocytes and by acute B-cell lymphoblastic leukemia cells. Therefore, CD10 appears to be involved in late stage regulation of hematopoietic cells (3).
Species Reactivity
Species reactivity is determined by testing in at least one approved application (e.g., western blot).
Applications Key
FC-FP: Flow Cytometry (Fixed/Permeabilized)
Cross-Reactivity Key
H: human M: mouse R: rat Hm: hamster Mk: monkey Vir: virus Mi: mink C: chicken Dm: D. melanogaster X: Xenopus Z: zebrafish B: bovine Dg: dog Pg: pig Sc: S. cerevisiae Ce: C. elegans Hr: horse GP: Guinea Pig Rab: rabbit All: all species expected
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