IHC-Bond, IHC-P
H
Endogenous
Mouse IgG2a
#P20023
1380
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| IHC Leica Bond | 1:200 - 1:800 |
| Immunohistochemistry (Paraffin) | 1:50 - 1:200 |
Storage
Specificity / Sensitivity
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a prokaryotic recombinant protein corresponding to the external domain of human CD21/CR2 protein.
Background
Complement receptor type 2 (CD21/CR2) is a type 1 transmembrane glycoprotein whose expression is largely restricted to B lymphocytes and follicular dendritic cells (1,2). Research studies have shown that CD21/CR2 functions to bind the complement fragments iC3b, C3dg, and C3d, which function to activate the alternative complement pathway and MAC formation (3,4). In addition to its function as a complement receptor, CD21/CR2 also functions as the B lymphocyte receptor for Epstein-Barr virus (5) and interferon alpha (6). Research studies have also shown that CD21/CR2 participates in B cell activation, proliferation, and protection from apoptosis through its association with components of the B cell coreceptor signaling complex such as CD19 and CD21 (7-9).
- Nadler, L.M. et al. (1981) J Immunol 126, 1941-7.
- Reynes, M. et al. (1985) J Immunol 135, 2687-94.
- Weis, J.J. et al. (1984) Proc Natl Acad Sci U S A 81, 881-5.
- Nielsen, C.H. et al. (2001) Immunology 104, 418-22.
- Fingeroth, J.D. et al. (1984) Proc Natl Acad Sci U S A 81, 4510-4.
- Asokan, R. et al. (2006) J Immunol 177, 383-94.
- Tedder, T.F. et al. (1994) Immunol Today 15, 437-42.
- Fearon, D.T. and Carter, R.H. (1995) Annu Rev Immunol 13, 127-49.
- Mongini, P.K. et al. (2003) J Immunol 171, 5244-54.
Species Reactivity
Species reactivity is determined by testing in at least one approved application (e.g., western blot).
Applications Key
IHC-Bond: IHC Leica Bond IHC-P: Immunohistochemistry (Paraffin)
Cross-Reactivity Key
H: human M: mouse R: rat Hm: hamster Mk: monkey Vir: virus Mi: mink C: chicken Dm: D. melanogaster X: Xenopus Z: zebrafish B: bovine Dg: dog Pg: pig Sc: S. cerevisiae Ce: C. elegans Hr: horse GP: Guinea Pig Rab: rabbit All: all species expected
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