WB, IHC-P
H
Endogenous
50-200
Rabbit IgG
#P40199
4680
Product Information
Product Usage Information
This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT&RUN or CUT&Tag assays. If you require a carrier free formulation for chromatin profiling, please contact us. Optimal dilutions/concentrations should be determined by the end user.
Formulation
Storage
Specificity / Sensitivity
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys246 of human CEACAM6 protein.
Background
Carcinoembryonic antigen (CEA)-related cell adhesion molecule 6 (CEACAM6) is a member of the CEA-related cell adhesion molecule (CEACAM) family (1). CEACAMs bind to themselves and other family members to carry out numerous cellular functions, including proliferation, signaling, differentiation, tumor suppression, and survival (2). CEACAM6 is a single-chain, glycosylphosphatidylinositol (GPI)-anchored, highly glycosylated protein that is normally expressed on epithelial cells and granulocytes (3,4). CEACAM6 mediates homophilic and heterophilic cell adhesion with other CEA-related cell adhesion molecules, such as CEACAM5 and CEACAM8 (3-6). Heterophilic interaction with CEACAM8 occurs in activated neutrophils (7), and plays a role in neutrophil adhesion to cytokine-activated endothelial cells (4). High levels of CEACAM6 expression are also observed in several different cancers (8-10). In cancer, CEACAM6 promotes tumor progression, migration, invasion, and metastasis, and therefore is considered a target for therapeutic intervention (11-13).
- Kuespert, K. et al. (2006) Curr Opin Cell Biol 18, 565-71.
- Bonsor, D.A. et al. (2015) Proc Natl Acad Sci U S A 112, 13561-6.
- Kuroki, M. et al. (2001) J Leukoc Biol 70, 543-50.
- Kuijpers, T.W. et al. (1992) J Cell Biol 118, 457-66.
- Oikawa, S. et al. (1989) Biochem Biophys Res Commun 164, 39-45.
- Oikawa, S. et al. (1991) J Biol Chem 266, 7995-8001.
- Skubitz, K.M. et al. (1996) J Leukoc Biol 60, 106-17.
- Duxbury, M.S. et al. (2004) Br J Cancer 91, 1384-90.
- Schölzel, S. et al. (2000) Am J Pathol 156, 595-605.
- Beauchemin, N. and Arabzadeh, A. (2013) Cancer Metastasis Rev 32, 643-71.
- Zhang, Y. et al. (2014) Acta Biochim Biophys Sin (Shanghai) 46, 283-90.
- Blumenthal, R.D. et al. (2005) Cancer Res 65, 8809-17.
- Ru, G.Q. et al. (2017) Oncotarget 8, 83673-83683.
Species Reactivity
Species reactivity is determined by testing in at least one approved application (e.g., western blot).
Applications Key
WB: Western Blotting IHC-P: Immunohistochemistry (Paraffin)
Cross-Reactivity Key
H: human M: mouse R: rat Hm: hamster Mk: monkey Vir: virus Mi: mink C: chicken Dm: D. melanogaster X: Xenopus Z: zebrafish B: bovine Dg: dog Pg: pig Sc: S. cerevisiae Ce: C. elegans Hr: horse GP: Guinea Pig Rab: rabbit All: all species expected
Trademarks and Patents
Limited Uses
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