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2663
Deltex-2 Antibody
Primary Antibodies

Deltex-2 Antibody #2663

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Supporting Data

REACTIVITY
SENSITIVITY
MW (kDa) 70
SOURCE Rabbit

Application Key:

  • W-Western
  • IP-Immunoprecipitation
  • IHC-Immunohistochemistry
  • ChIP-Chromatin Immunoprecipitation
  • IF-Immunofluorescence
  • F-Flow Cytometry
  • E-P-ELISA-Peptide

Species Cross-Reactivity Key:

  • H-Human
  • M-Mouse
  • R-Rat
  • Hm-Hamster
  • Mk-Monkey
  • Mi-Mink
  • C-Chicken
  • Dm-D. melanogaster
  • X-Xenopus
  • Z-Zebrafish
  • B-Bovine
  • Dg-Dog
  • Pg-Pig
  • Sc-S. cerevisiae
  • Ce-C. elegans
  • Hr-Horse
  • All-All Species Expected

Storage:

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

Deltex-2 Antibody detects transfected levels of total Deltex-2 protein.

Species predicted to react based on 100% sequence homology:

Human, Rat

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala607 of human Deltex-2. Antibodies are purified by protein A and peptide affinity chromatography.

Background

Deltex (DTX) encodes a putative E3 ubiquitin ligase first identified from Drosophila and shown to modulate Notch signaling (1). Several mammalian Deltex homologs have been isolated (2,3), all containing a pair of WWE repeats, a proline-rich region, and a Ring-finger domain (4,5). Deltex binds to the ankyrin-repeat domain of Notch and is capable of regulating Notch signaling positively or negatively in different systems (4,6). In addition, Deltex can also form homo-multimers (4). While Deltex has been implicated in Notch signaling regulation of lymphocyte development, this signal modifier may also have a transcriptional function independent of Notch (3, 6-8).

  1. Xu, T. and Artavanis-Tsakonas, S. (1990) Genetics 126, 665-77.
  2. Kishi, N. et al. (2001) Int J Dev Neurosci 19, 21-35.
  3. Lehar, S.M. and Bevan, M.J. (2006) Mol Cell Biol 26, 7358-71.
  4. Matsuno, K. et al. (1995) Development 121, 2633-44.
  5. Zweifel, M.E. et al. (2005) Structure 13, 1599-611.
  6. Izon, D.J. et al. (2002) Immunity 16, 231-43.
  7. Yun, T.J. and Bevan, M.J. (2003) J Immunol 170, 5834-41.
  8. Yamamoto, N. et al. (2001) J Biol Chem 276, 45031-40.

Pathways & Proteins

Explore pathways + proteins related to this product.

For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

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