Revision 1
#57551
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For Research Use Only. Not for Use in Diagnostic Procedures.
Applications:
W
Reactivity:
H
Sensitivity:
Endogenous
MW (kDa):
78
Source/Isotype:
Rabbit IgG
UniProt ID:
#Q96AY3
Entrez-Gene Id:
60681
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Specificity/Sensitivity
Source / Purification
Background
FKBP10, also known as FKBP65 (65 kDa FK506-binding protein), has four tandem PPIase domains and is an endoplasmic reticulum (ER) resident protein, where it modulates the folding and trafficking of secretory proteins. FKBP10 plays an important role in collagen folding and secretion and its mutation is associated with osteogenesis imperfecta (4-6), and it is considered as a therapeutic target for idiopathic pulmonary fibrosis (IPF) (7,8). Recent reports suggest that FKBP10 may be a biomarker or therapeutic target for several different cancers (9-11).
Background References
- Bonner, J.M. and Boulianne, G.L. (2017) Cell Signal 38, 97-105.
- Tong, M. and Jiang, Y. (2015) Curr Mol Pharmacol 9, 48-65.
- Ghartey-Kwansah, G. et al. (2018) BMC Dev Biol 18, 7.
- Ishikawa, Y. et al. (2017) J Biol Chem 292, 17216-17224.
- Li, S. et al. (2020) Front Genet 11, 984.
- Lietman, C.D. et al. (2017) J Bone Miner Res 32, 1354-1367.
- Staab-Weijnitz, C.A. et al. (2015) Am J Respir Crit Care Med 192, 455-67.
- Knüppel, L. et al. (2018) Respir Res 19, 67.
- Ge, Y. et al. (2017) Urol Int 98, 169-176.
- Liang, L. et al. (2019) Oncol Rep 42, 615-628.
- Gong, L.B. et al. (2020) Onco Targets Ther 13, 7399-7409.
Species Reactivity
Species reactivity is determined by testing in at least one approved application (e.g., western blot).
Western Blot Buffer
IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 5% w/v BSA, 1X TBS, 0.1% Tween® 20 at 4°C with gentle shaking, overnight.
Applications Key
W: Western Blotting
Cross-Reactivity Key
H: Human
Trademarks and Patents
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Limited Uses
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