IHC-P
H M
Endogenous
32
Rabbit IgG
#Q16270
3490
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Immunohistochemistry (Paraffin) | 1:50 - 1:200 |
Storage
Specificity / Sensitivity
Species Reactivity:
Human, Mouse
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu241 of human IGFBP7 protein.
Background
IGFBP7 (also known as Mac25, TAF, or IGFBP-rP1) belongs to the IGFBP superfamily, which plays an integral role in regulating insulin-like growth factor (IGF) actions in a wide variety of cell types. There are six known high-affinity IGF binding family members (IGFBP1-6), and ten low-affinity IGF binding members. These family members are structurally related, but encoded by distinct genes (1,2). IGFBP7 is a low-affinity IGF binding protein (1). The protein functions through its binding to secreted growth factors including IGF1, insulin, and activin (3,4). IGFBP7 levels have been related to cancer development and tissue injury. Loss of expression of IGFBP7 has been associated with poor survival in multiple cancer types (5,6) and with tumor chemotherapy resistance (7,8). IGFBP7 also has been identified as a cell cycle arrest biomarker for human acute kidney injury (AKI) and serves as a prognostic indicator for early stage AKI development (9-11).
- Hwa, V. et al. (1999) Endocr Rev 20, 761-87.
- Duan, C. (2002) J Endocrinol 175, 41-54.
- Yamanaka, Y. et al. (1997) J Biol Chem 272, 30729-34.
- Kato, M.V. (2000) Mol Med 6, 126-35.
- Akiel, M. et al. (2014) J Hepatocell Carcinoma 1, 9-19.
- Benatar, T. et al. (2012) Breast Cancer Res Treat 133, 563-73.
- Verhagen, H.J. et al. (2014) Cell Death Dis 5, e1300.
- Okamura, J. et al. (2012) Cancer Biol Ther 13, 148-55.
- Kashani, K. et al. (2013) Crit Care 17, R25.
- Kellum, J.A. and Chawla, L.S. (2016) Nephrol Dial Transplant 31, 16-22.
- Gocze, I. et al. (2015) PLoS One 10, e0120863.
Species Reactivity
Species reactivity is determined by testing in at least one approved application (e.g., western blot).
Applications Key
IHC-P: Immunohistochemistry (Paraffin)
Cross-Reactivity Key
H: human M: mouse R: rat Hm: hamster Mk: monkey Vir: virus Mi: mink C: chicken Dm: D. melanogaster X: Xenopus Z: zebrafish B: bovine Dg: dog Pg: pig Sc: S. cerevisiae Ce: C. elegans Hr: horse GP: Guinea Pig Rab: rabbit All: all species expected
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