Revision 1
#49938
Store at -20C
Microglia Proliferation Module Antibody Sampler Kit
1 Kit
(7 x 20 microliters)
877-616-CELL (2355)
877-678-TECH (8324)
3 Trask Lane | Danvers | Massachusetts | 01923 | USA
For Research Use Only. Not for Use in Diagnostic Procedures.
| Product Includes | Product # | Quantity | Mol. Wt | Isotype/Source |
|---|---|---|---|---|
| HS1 (D5A9) Rabbit Monoclonal Antibody | 3892 | 20 µl | 80 kDa | Rabbit IgG |
| ASC/TMS1 (D2W8U) Rabbit Monoclonal Antibody | 67824 | 20 µl | 22 kDa | Rabbit IgG |
| Ki-67 (D3B5) Rabbit Monoclonal Antibody | 9129 | 20 µl | Rabbit IgG | |
| MCM2 (D7G11) Rabbit Monoclonal Antibody | 3619 | 20 µl | 125 kDa | Rabbit IgG |
| Survivin (71G4B7) Rabbit Monoclonal Antibody | 2808 | 20 µl | 16 kDa | Rabbit IgG |
| HP1 alpha/beta (C7F11) Rabbit Monoclonal Antibody | 2623 | 20 µl | 25 kDa | Rabbit IgG |
| Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) (D13A11) Rabbit Monoclonal Antibody | 2914 | 20 µl | 35, 40, 48 kDa | Rabbit IgG |
| Anti-rabbit IgG, HRP-linked Antibody | 7074 | 100 µl | Goat |
Please visit cellsignal.com for individual component applications, species cross-reactivity, dilutions, protocols, and additional product information.
Description
Storage
Background
Ki-67 is a nuclear nonhistone protein (5) universally expressed among proliferating cells and absent in quiescent cells (6). Minichromosome maintenance protein 2 (MCM2) is a nuclear protein that plays a role in DNA replication and cell division (7) and is commonly used as a marker for cell proliferation, including brain tissue (8). Survivin binds and inhibits caspase-3, controlling the checkpoint in the G2/M-phase of the cell cycle by inhibiting apoptosis and promoting cell division (9). Aurora A, B, and C are a family of highly conserved serine/threonine kinases that regulate chromosomal alignment and segregation during mitosis and meiosis. Their activity requires autophosphorylation of a threonine within their kinase domain at site Thr288 of Aurora A, Thr232 of Aurora B, and Thr198 of Aurora C (10). Heterochromatin protein 1 (HP1) α and β are heterochromatic adaptor molecules involved in both gene silencing and higher order chromatin structure (11).
Background References
- Friedman, B.A. et al. (2018) Cell Rep 22, 832-47.
- Zhang, Y. et al. (2014) J Neurosci 34, 11929-47.
- Kitamura, D. et al. (1995) Biochem Biophys Res Commun 208, 1137-46.
- Srinivasula, S.M. et al. (2002) J Biol Chem 277, 21119-22.
- Gerdes, J. et al. (1983) Int J Cancer 31, 13-20.
- Weigel, M.T. and Dowsett, M. (2010) Endocr Relat Cancer 17, R245-62.
- Mincheva, A. et al. (1994) Cytogenet Cell Genet 65, 276-7.
- Doorn, K.J. et al. (2014) Neural Plast 2014, 959154.
- Li, F. et al. (1999) Nat Cell Biol 1, 461-6.
- Goldenson, B. and Crispino, J.D. (2015) Oncogene 34, 537-45.
- Maison, C. and Almouzni, G. (2004) Nat Rev Mol Cell Biol 5, 296-304.
Trademarks and Patents
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
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Limited Uses
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