WB, IHC-Bond, IHC-P
H
Endogenous
76
Rabbit IgG
#P20591
4599
Product Information
Product Usage Information
This product is the carrier free version of product #37849. All were was generated using the same antibody clone in the standard formulation which contains BSA and glycerol.
This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT&RUN, or CUT&Tag assays. If you require a carrier-free formulation for chromatin profiling, please contact us. Optimal dilutions/concentrations should be determined by the end user.
Formulation
Storage
Specificity / Sensitivity
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu292 of human MX1 protein.
Background
MX1 (Myxovirus resistance protein 1/MxA) is an interferon-inducible antiviral protein that confers resistance to RNA viruses (1-4). MX1 has GTPase activity, and GTP-bound MX1 adopts a conformation that enables interaction with viral nucleocapsids (5-7). This interaction blocks transport of viral nucleocapsids to the nucleus, which prevents transcription of the viral genome (7,8). Structural studies suggest that the antiviral activity of MX1 involves the formation of MX1 oligomeric rings around viral nucleocapsids (9-12).
- Horisberger, M.A. and Hochkeppel, H.K. (1985) J Biol Chem 260, 1730-3.
- Staeheli, P. et al. (1985) J Biol Chem 260, 1821-5.
- Staeheli, P. and Haller, O. (1985) Mol Cell Biol 5, 2150-3.
- Staeheli, P. et al. (1986) Cell 44, 147-58.
- Nakayama, M. et al. (1991) J Biol Chem 266, 21404-8.
- Kochs, G. and Haller, O. (1999) J Biol Chem 274, 4370-6.
- Kochs, G. and Haller, O. (1999) Proc Natl Acad Sci U S A 96, 2082-6.
- Kochs, G. et al. (2002) Proc Natl Acad Sci U S A 99, 3153-8.
- Kochs, G. et al. (2002) J Biol Chem 277, 14172-6.
- Gao, S. et al. (2010) Nature 465, 502-6.
- Haller, O. et al. (2010) J Biol Chem 285, 28419-24.
- Gao, S. et al. (2011) Immunity 35, 514-25.
Species Reactivity
Species reactivity is determined by testing in at least one approved application (e.g., western blot).
Applications Key
WB: Western Blotting IHC-Bond: IHC Leica Bond IHC-P: Immunohistochemistry (Paraffin)
Cross-Reactivity Key
H: human M: mouse R: rat Hm: hamster Mk: monkey Vir: virus Mi: mink C: chicken Dm: D. melanogaster X: Xenopus Z: zebrafish B: bovine Dg: dog Pg: pig Sc: S. cerevisiae Ce: C. elegans Hr: horse GP: Guinea Pig Rab: rabbit All: all species expected
Trademarks and Patents
Limited Uses
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