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Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

SDH5 Antibody recognizes endogenous levels of total SDH5 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu153 of human SDH5 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Succinate dehydrogenase subunit 5 (SDH5, SDHAF2) is a subunit of the succinate dehydrogenase (SDH) protein complex responsible for the oxidation of succinate during the citric acid cycle. Mitochondrial SDH5 associates with the catalytic subunit of succinate dehydrogenase and is required for adding FAD cofactor to the SDH catalytic subunit (1). Mutations in the corresponding SDHAF2 gene are associated with hereditary head and neck paragangliomas, an autosomal disorder characterized by the development of tumors with increased penetrance over time (1). Additional research studies show that SDH5 is involved in the regulation of lung cancer metastasis mediated by the glycogen synthase kinase 3β and β-catenin signaling pathways (2).

1.  Hao, H.X. et al. (2009) Science 325, 1139-42.

2.  Liu, J. et al. (2013) J Biol Chem 288, 29965-73.

Entrez-Gene Id 54949
Swiss-Prot Acc. Q9NX18

For Research Use Only. Not For Use In Diagnostic Procedures.
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SDH5 Antibody