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5837
GβL (86B8) Rabbit mAb (Sepharose® Bead Conjugate)

GβL (86B8) Rabbit mAb (Sepharose® Bead Conjugate) #5837

This product is discontinued

Storage:

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol. Store at –20°C. Do not aliquot the antibodies.

GβL (86B8) Rabbit mAb (Sepharose® Bead Conjugate) detects endogenous levels of total GβL protein.

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln210 of human GβL protein.

This Cell Signaling Technology antibody is immobilized via covalent binding of primary amino groups to N-hydroxysuccinimide (NHS)-activated Sepharose® beads. GβL (86B8) Rabbit mAb (Sepharose® Bead Conjugate) is useful for the immunoprecipitation of GβL protein.

Cell growth is a fundamental biological process whereby cells accumulate mass and increase in size. The mammalian Target of Rapamycin (mTOR) pathway regulates growth by coordinating energy and nutrient signals with growth factor-derived signals (1). mTOR is a large protein kinase with two different complexes. One complex contains mTOR, GβL, and raptor, which is a target of rapamycin. The other complex, insensitive to rapamycin, includes mTOR, GβL, and rictor (1). GβL associates with the kinase domain of mTOR and stimulates mTOR kinase activity (2). A reduction in GβL expression has been shown to decrease in vivo phosphorylation of S6K1 (2).

  1. Sarbassov, D.D. et al. (2004) Curr Biol 14, 1296-302.
  2. Kim, D.H. et al. (2003) Mol. Cell 11, 895-904.
Entrez-Gene Id
64223
Swiss-Prot Acc.
Q9BVC4
For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
U.S. Patent No. 7,429,487, foreign equivalents, and child patents deriving therefrom.

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