Epigenetics is defined as the study of heritable phenotypic changes in organisms that do not involve alterations to the DNA sequence. In other words, epigenetics involves the study of DNA modifications, histone modification, and chromatin- regulatory proteins that regulate heritable changes in gene expression. Understanding epigenetic drivers of disease is critical in the detection and prevention of transcriptional abnormalities found in cancer as well as some metabolic, neurological, inflammatory, and cardiovascular disorders. The ability to interrogate epigenetic changes in cells and tissues could provide insights into causative mechanisms of disease and normal function and development. Towards this goal, Cell Signaling Technology (CST) provides a comprehensive platform including a diverse catalog of products, epigenetics assays, and resources such as the PhosphoSitePlus® database.