PTMScan® Direct Apoptosis / Autophagy Service allows access to perform targeted screening and quantification of a defined set of protein sites within the or related to the Apoptosis or Autophagy pathways that are critical for drug discovery, biomarker discovery, or diagnostic development. The table below illustrates the list of protein sites that can be monitored with PTMScan® Direct Apoptosis / Autophagy Service.
Altogether, the PTMScan® Direct Apoptosis / Autophagy service provides a robust method to qualitatively identify and quantitatively profile 175 unique sites of phosphorylation and caspase cleavage on 100 proteins.
| Apoptosis / Autophagy Protein Sites | |||
|---|---|---|---|
| Apoptosis / Autophagy Protein Sites | |||
| α-Tubulin | Akt1 | Akt1 (Ser473) | Akt1 (Ser477) |
| Akt1 (Thr305) | Akt1 (Thr308) | Akt1 (Thr312) | Akt1 (Thr479) |
| Akt1 (Tyr315) | Akt1 (Tyr474) | Akt2 (Ser302) | Akt2 (Thr306) |
| Akt2 (Thr309) | Akt2 (Thr313) | Akt2 (Tyr316) | Akt3 (Ser472) |
| Akt3 (Ser474) | Akt3 (Ser476) | Akt3 (Thr302) | Akt3 (Thr305) |
| Akt3 (Thr309) | Akt3 (Tyr473) | ANXA5 | API5 |
| ARC | ATG12 | ATG12 (Ser41) | ATG12 (Thr30) |
| ATG3 | ATG4C | ATG7 | ATG9A |
| β-Actin | BAD (Ser97) | BAD (Ser99) | Bak1 |
| Bcl-11B | Bcl-9L | Bcl-9L (Thr1370) | Bcl-xL |
| Bid | BIRC6 | Casp2 | Casp3 |
| Casp3 (Asp175) | Casp3 (Ser176) | Casp6 | Casp6 (Asp179) |
| Casp7 | Casp7 (Asp198) | Casp7 (Ser199) | Casp8 (Asp374) |
| Casp9 | Casp9 (Asp315) | Casp9 (Ser302) | Casp9 (Ser307) |
| CCAR1 | CCDC72 | CIAPIN1 | CLU |
| CYC1 | CYCS | DBC-1 | DBC-1 (Ser124) |
| DDAH2 | DNA-PK | ERK1 (Thr198) | ERK1 (Thr202) |
| ERK1 (Tyr204) | ERK2 (Thr181) | ERK2 (Thr185) | ERK2 (Thr190) |
| ERK2 (Tyr187) | Fas | Fas (Asp269) | FYCO1 |
| G6PI | GAPDH | GRP94 | GSK3A (Thr19) |
| H3 | HELLS | IκBα (Ser32) | IκBα (Ser36) |
| IκBα (Tyr42) | IκBε (Ser18) | IκBε (Ser22) | IκBε (Ser25) |
| IKKβ | Jun (Ser58) | Jun (Ser63) | Jun (Ser73) |
| Jun (Thr62) | JunD (Ser100) | JunD (Ser90) | LDH-A |
| MIF | MMRP19 | mTOR | mTOR (Ser2478) |
| mTOR (Ser2481) | mTOR (Thr2471) | mTOR (Thr2473) | mTOR (Thr2474) |
| Myc | NF-κB p105 | NF-κB p105 (Ser923) | NF-κB p105 (Ser927) |
| NF-κB p105 (Ser932) | NF-κB p65 | NF-κB p65 (Asp512) | NF-κB p65 (Ser536) |
| Nik (Thr764) | Nudt2 | p400 | PAR-4 (Asp131) |
| PARP1 | PDCD10 | PDCD5 | PDCD8 |
| PDCL3 | PHLDA1 | PI4K2A (Thr76) | PIK3C2A |
| PIK3C3 | PIK3CA | PIK3CA (Ser507) | PIK3CA (Tyr508) |
| PIK3CB | PIK3CD | PIK4CA | PIP5K2A |
| PKCA | PKCA (Thr494) | PKCA (Thr501) | PKCB |
| PKCB (Thr497) | PKCB (Thr500) | PKCB (Thr504) | PKCB (Tyr507) |
| PKCH | PKCT (Thr275) | PKD1 (Ser473) | PKD1 (Ser738) |
| PKD2 (Ser706) | PKD3 (Ser731) | PRAS40 | PRAS40 (Ser203) |
| PRAS40 (Thr266) | RABGAP1 | Raptor | Raptor (Ser877) |
| Raptor (Ser886) | Raptor (Thr883) | Raptor (Thr889) | Rictor |
| ROCK1 | ROCK2 | RUSC1 | SH3GLB1 |
| SH3GLB2 | SHP-2 | SHP-2 (Ser580) | SHP-2 (Tyr584) |
| SOD1 | STAG1 | Survivin | Survivin (Asp72) |
| TNF-R1 | ULK1 (Ser556) | ULK4 (Thr645) | XIAP |
| ZNF768 (Ser17) | ZNF768 (Ser18) | ZNF768 (Ser23) | |
