SAM Protein Domain

The SAM domain from the EphA4 receptor.

Domain Binding and Function

The approximately 70 amino acid SAM (Sterile α Motif) domain has been identified from over 400 different proteins responsible for diverse cellular functions in organisms from yeast to man. SAM domains are implicated in mediating protein-protein interactions by forming homo- and heterotypic oligomers. The residues at the interface of the EphA4 and EphB2 SAM domain homodimers have been mapped, but the factors that determine specificity remain unclear.

Structure Reference

1. Stapleton, D. et al. (1999) Nat. Struct. Biol. 6(1), 44–49.

Examples of Domain Proteins

Binding Examples