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17-AAG #8132

    Product Information

    Product Usage Information

    17-AAG is supplied as a lyophilized powder. For a 1 mM stock, reconstitute the 500 μg in 853.7 μl DMSO. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used at 0.1-1 μM for 4-24 hours. Soluble in DMSO at 150 mg/mL; soluble in ethanol at 5 mg/mL. Maximum solubility in plain water estimated to be about 20-50 μM.

    Storage

    Store lyophilized or in solution at -20ºC, desiccated. Protect from light. In lyophilized form, the chemical is stable for 24 months. Once in solution, use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 585.7 g/mol
    Purity >98%
    Molecular Formula C31H43N3O8
    CAS 75747-14-7
    Solubility Soluble in DMSO at 50mg/ml or EtOH at 5mg/ml.

    Background

    17-AAG is a semi-synthetic derivative of geldanamycin, demonstrating greater stability than its parent compound (1). It binds specifically to heat shock protein HSP90 in a manner similar to geldanamycin, but with weaker binding (1). Through specific binding with HSP90, 17-AAG has been shown to decrease levels of many proteins including androgen receptor (AR), HER2, and Akt, while increasing levels of HSP90 in prostate cancer cell lines (2). 17-AAG binds to a conserved pocket in the HSP90 family of chaperone proteins and this occupation causes the degradation of several signaling proteins (2).

    Alternate Names

    17-Allylaminogeldanamycin; 17-Allylaminogeldanamycin; 17aag; 17Allylamino geldanamycin; geldanamycin; HSP90; Tanespimycin

    For Research Use Only. Not for Use in Diagnostic Procedures.
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