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  3. 2’,3’-cGAMP (sodium salt)

2’,3’-cGAMP (sodium salt) #35573

    Product Information

    Product Usage Information

    2’,3’-cGAMP (sodium salt) is supplied as a lyophilized powder. For a 5 mM stock, reconstitute 500 μg of powder in 139 μl of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, continue to store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 718.4 g/mol
    Purity >98%
    Molecular Formula C20H22N10Na2O13P2
    CAS 1441190-66-4
    Solubility Soluble in DMSO at 50 mg/ml or water at 10 mg/ml.

    Background

    2’,3’-cGAMP (sodium salt), also known as 2’,3’-cyclic-GMP-AMP, is a second messenger produced by the enzyme cGAMP synthase (cGAS) in response to cytoplasmic DNA (1,2). cGAMP binds and activates the stimulator of interferon genes (STING), a transmembrane adaptor protein that is a critical component of the cellular innate immune response to pathogenic cytoplasmic DNA (1-4). The binding affinity of 2’,3’-cGAMP to STING is stronger than other cyclic di-nucleotides such as c-di-GMP, 3′2′-cGAMP, 3′3′-cGAMP, and 2′2′-cGAMP with a reported Kd value of 3.79 nM compared to 1.21 μM, 1.61 μM, 1.04 μM, and 287 nM, respectively (5).

    Alternate Names

    2'-3'-Cyclic GMP-AMP; Guanosine-Adenosine 2',3'-cyclic monophosphate

    Limited Uses

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    For Research Use Only. Not for Use in Diagnostic Procedures.
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