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79508
AM-580
Activators & Inhibitors
Chemical Modulators

AM-580 #79508

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AM-580: Image 1
Chemical structure of AM-580.

Product Usage Information

AM-580 is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 0.95 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight 351.4 g/mol
Purity >98%
Molecular Formula C22H25NO33
CAS 102121-60-8
Solubility Soluble in DMSO at 35 mg/mL or ethanol at 18 mg/mL.

Background

The synthetic retinoic acid analog AM-580 displays high selectivity for nuclear retinoic acid receptors (RAR), binding RARα more potently (EC50 = 0.3 nM) than either RARβ (EC50 = 8.6 nM) or RARγ (EC50 = 13 nM) (1,2). Signaling pathways controlled by retinoic acid coordinate cell proliferation, differentiation, apoptosis, and development of many organs and tissues (3). Treatment of a mouse model of Alzheimer's Disease (AD) with the retinoid receptor agonist AM-580 produced an anti-inflammatory effect and regulated the neurotoxic activation of microglia, shifting microglial activity toward a neuroprotective phenotype (4). AM-580 also interrupts the life cycle of diverse viruses by inhibiting host lipid biosynthesis through interaction with sterol regulatory element binding protein (SREBP), which binds sterol response elements in the promoter/enhancer regions of multiple lipogenic genes (5). In a screen of multiple antiviral agents, AM-580 exhibited anti-SARS-CoV-2 activity, with AM-580 treatment producing a substantial reduction in viral load (6).
  1. Martin, B. et al. (1992) Skin Pharmacol 5, 57-65.
  2. Charton, J. et al. (2009) Bioorg Med Chem Lett 19, 489-92.
  3. Ghyselinck, N.B. and Duester, G. (2019) Development 146, dev167502. doi: 10.1242/dev.167502.
  4. Ganz, T. et al. (2022) J Neuroinflammation 19, 5.
  5. Yuan, S. et al. (2019) Nat Commun 10, 120.
  6. Yuan, S. et al. (2020) Viruses 12, 628. doi: 10.3390/v12060628.

Limited Uses

Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.

Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

For Research Use Only. Not For Use In Diagnostic Procedures.
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To Purchase # 79508
Cat. # Size Qty. Price
79508S
5 mg
$ 116