View Featured Offers >>
Antimycin A
Activators & Inhibitors
Chemical Modulators

Antimycin A #33357

Citations (0)
Chemical structure of Antimycin A.

Product Usage Information

Antimycin A is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 10 mg of powder in 1.2 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.


Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight 548.6 g/mol
Purity >97%
Molecular Formula C28H40N2O9
CAS 1397-94-0
Solubility Soluble in DMSO at 35 mg/mL or ethanol at 50 mg/mL.


Antimycin A is an inhibitor of electron transport from cytochrome b to cytochrome complex III (cytochrome c reductase). Binding of Antimycin A to cytochrome c reductase inhibits the oxidation of ubiquinol, disrupts the Q-cycle of enzyme turnover, and halts cellular respiration (1). Consequently, this small, non-peptide ligand inhibitor has been used for decades to characterize the mitochondrial respiratory chain (2). Antimycin A has long been used as a piscicide in commercial fish farms, and possesses strong antifungal, insecticidal, and nematocidal activities (3). Treatment of HeLa cells with Antimycin A results in the loss of mitochondrial membrane potential and inhibition of cell growth through apoptosis. Antimycin A strongly generates reactive oxygen species and induces glutathione depletion in these cells (4). Antimycin A binds and inhibits Bcl2/Bcl-xL-related anti-apoptotic proteins, which are commonly over-produced by cancer cells (5,6).

Limited Uses

Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.

Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

For Research Use Only. Not for Use in Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
All other trademarks are the property of their respective owners. Visit our Trademark Information page.
To Purchase # 33357
Cat. # Size Qty. Price
10 mg