Antimycin A #33357
Product Information
Product Usage Information
Storage
Product Description
| Molecular Weight | 548.6 g/mol |
| Purity | >97% |
| Molecular Formula | C28H40N2O9 |
| CAS | 1397-94-0 |
| Solubility | Soluble in DMSO at 35 mg/mL or ethanol at 50 mg/mL. |
Background
Antimycin A is an inhibitor of electron transport from cytochrome b to cytochrome complex III (cytochrome c reductase). Binding of Antimycin A to cytochrome c reductase inhibits the oxidation of ubiquinol, disrupts the Q-cycle of enzyme turnover, and halts cellular respiration (1). Consequently, this small, non-peptide ligand inhibitor has been used for decades to characterize the mitochondrial respiratory chain (2). Antimycin A has long been used as a piscicide in commercial fish farms, and possesses strong antifungal, insecticidal, and nematocidal activities (3). Treatment of HeLa cells with Antimycin A results in the loss of mitochondrial membrane potential and inhibition of cell growth through apoptosis. Antimycin A strongly generates reactive oxygen species and induces glutathione depletion in these cells (4). Antimycin A binds and inhibits Bcl2/Bcl-xL-related anti-apoptotic proteins, which are commonly over-produced by cancer cells (5,6).
- Cramer, W.A. et al. (2011) Biochim Biophys Acta 1807, 788-802.
- Labs, M. et al. (2016) Photosynth Res 129, 231-8.
- Lennon, R.E. (1973) Adv Appl Microbiol 16, 55-96.
- Park, W.H. et al. (2007) J Cell Biochem 102, 98-109.
- Tzung, S.P. et al. (2001) Nat Cell Biol 3, 183-91.
- Kim, K.M. et al. (2001) Biochemistry 40, 4911-22.
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