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Angiomotin (E3E7X) Rabbit Monoclonal Antibody

Angiomotin (E3E7X) Rabbit Monoclonal Antibody #51142

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Product Specifications

REACTIVITY	H
SENSITIVITY	Endogenous
MW (kDa)	140, 130, 100
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

H-Human

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

Angiomotin (E3E7X) Rabbit Monoclonal Antibody recognizes endogenous levels of angiomotin isoform 1 (full-length) protein. This antibody does not recognize the amino-terminally truncated angiomotin isoform 2 protein. This antibody cross-reacts with the angiomotin family members, angiomotin-like 1 (AMOTL1) and angiomotin-like 2 (AMOTL2).

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human angiomotin protein.

Background

Angiomotin (AMOT) is a widely expressed cell junction protein initially identified through its ability to bind angiostatin. Alternative splicing results in two isoforms of angiomotin, the full-length p130 and the amino-terminally truncated p80. These isoforms, along with angiomotin-like 1 (AMOTL1) and angiomotin-like 2 (AMOTL2), comprise the Motin protein family. Angiomotin is important in endothelial cell polarity, migration, and blood vessel formation during development, as well as in signaling through small GTPases and the Hippo/YAP pathway (reviewed in 1). Research studies have shown that angiomotin expression regulates migration and proliferation of breast cancer cells (2,3).

Alternate Names

AMOT; Angiomotin; angiomotin p130 isoform; angiomotin p80 isoform; KIAA1071

Database Links

UniProt ID: Q4VCS5

Entrez-Gene Id: 154796

Limited Uses

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For Research Use Only. Not for Use in Diagnostic Procedures.

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