Cell Signaling Technology is proud to partner with the Koch Institute at MIT, Science, and Science Signaling to present a series of webinars focused on “Targeting Cancer Pathways.”

We will be updating this page as information becomes available, so check back often.

Understanding immune checkpoints

In this webinar, we will explore how tumors utilize immune checkpoint proteins to generate and thrive in their own immunosuppressive microenvironment and examine how these mechanisms can be targeted to develop better therapeutic options.

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Featured speakers:

  • James P. Allison, M.D
    M.D. Anderson Cancer Center
    Houston, TX
  • Gordon J. Freeman Ph.D.
    Dana-Farber Cancer Institute
    Boston, MA
  • Philip Gotwals, Ph.D.
    Executive Director, Oncology Research
    Boston, MA

The Epigenetics Question

Now Available on Demand

In this webinar we explore how aberrant changes in epigenetic modification can affect the expression of key genes and contribute to the pathological progression of cancer.

During the webinar, the speakers will:

  • Outline the major epigenetic changes seen in tumor tissue
  • Explain how specific epigenetic pathways can be targeted for therapeutic intervention
  • Introduce the role of histone modifications (methylation, acetylation, ubiquitylation, phosphorylation, etc.) in tumor survival and progression
  • Answer your questions live during the broadcast!

Featured speakers:

  • Stephen B. Baylin, M.D
    Johns Hopkins School of Medicine
    Baltimore, MD
  • Charles Roberts, M.D., Ph.D.
    Dana-Farber Cancer Institute
    Boston, MA
  • Ali Shilatifard, Ph.D.
    Northwestern University
    Feinberg School of Medicine
    Chicago, IL

Tumor Metabolism and Proliferation

Now Available on Demand

In this webinar we explore how cancer cells are able to reprogram their metabolic pathways to enable energy production under conditions that are disabling to most normal cells. Of particular interest are how tumor-specific metabolic changes promote oncogenic progression and how these changes can be exploited to develop more effective treatment options.

Featured speakers:

  • Nissim Hay, Ph.D.,
    University of Illinois
    Chicago, IL
  • M. Celeste Simon, Ph.D.
    University of Pennsylvania
    Philadelphia, PA

Tumor Microenvironment

Now Available on Demand

Here, we explore how the tumor microenvironment promotes oncogenic progression, while protecting the tumor from therapeutic intervention. By better understanding the tumor microenvironment we can develop strategies and treatment options to neutralize its oncogenic influence and more effectively attack the tumor itself.

Featured speakers:

  • Padmanee Sharma, M.D., Ph.D
    The University of Texas MD Anderson Cancer Center
    Houston, TX.
  • Rakesh Jain, Ph.D
    Massachusetts General Hospital, Harvard Medical School
    Boston, MA

Mechanisms of Tumor Resistance

Now Available on Demand

This webinar focuses on how the rewiring of signaling pathways in response to drug treatment contributes to tumor resistance and how this knowledge can be leveraged to develop more effective treatment strategies.

During this webinar, viewers will:

  • Gain an understanding of the specific molecules and pathways that are the targets for rationally designed therapies
  • Learn about efforts to overcome resistance to the first FDA-approved therapy targeting a hyperactive kinase
  • Review mechanisms by which tumor cells resist inhibitors that target cell survival and growth pathways
  • Hear how the rewiring of cell death pathways can sensitize cells to traditional chemotherapy agents

Featured Speakers:

  • Michael B. Yaffee, M.D., Ph.D
    Massachusetts Institute of Technology
    Cambridge, MA
  • Jeffrey Engelman, M.D., Ph.D
    Harvard Medical School
    Boston, MA
  • Michael W. Deininger, M.D., Ph.D
    University of Utah
    Salt Lake City, UT