| Product Includes | Product # | Quantity | Mol. Wt | Isotype/Source |
|---|---|---|---|---|
| IL-1β (D3U3E) Rabbit mAb | 12703 | 20 µl | 17, 31 kDa | Rabbit IgG |
| CCL5/RANTES (R40) Antibody | 2987 | 20 µl | 10 kDa | Rabbit |
| CXCL10 (D5L5L) Rabbit mAb | 14969 | 20 µl | 10 kDa | Rabbit IgG |
| PAI-1 (D9C4) Rabbit mAb | 11907 | 20 µl | 48 kDa | Rabbit IgG |
| IL-6 (D3K2N) Rabbit mAb | 12153 | 20 µl | 21-28 kDa | Rabbit IgG |
| TNF-α (D5G9) Rabbit mAb | 6945 | 20 µl | 18, 25 kDa | Rabbit IgG |
| MMP-3 (D7F5B) Rabbit mAb | 14351 | 20 µl | 60 kDa | Rabbit IgG |
| MCP-1 Antibody (Carboxy-terminal Antigen) | 39091 | 20 µl | 13-15 kDa | Rabbit |
| Anti-rabbit IgG, HRP-linked Antibody | 7074 | 100 µl | Goat |
Please visit cellsignal.com for individual component applications, species cross-reactivity, dilutions, protocols, and additional product information.
Description
Senescence Associated Secretory Phenotype (SASP) Antibody Sampler Kit provides an economical means of detecting multiple components of the SASP. The kit includes enough antibody to perform two western blot experiments with each primary antibody.
Background
Senescence is characterized by stable stress-induced proliferative arrest and resistance to mitogenic stimuli, as well as the secretion of proteins such as cytokines, growth factors and proteases. These secreted proteins comprise the senescence-associated secretory phenotype (SASP). Senescent cells are thought to accumulate as an organism ages, and contribute to age-related diseases, including cancer, through promotion of inflammation and disruption of normal cellular function (1,2). The composition of the SASP varies, and SASP components can be either beneficial or deleterious in human disease, depending on the context (3).
Senescence Associated Secretory Phenotype (SASP) Antibody Sampler Kit provides a collection of antibodies to various SASP components, including TNF-alpha, interleukin-6 (IL-6), the multifunctional cytokine IL-1beta, the chemokines CXCL10, RANTES/CCL5 and MCP-1, the matrix metalloprotease MMP3, and the serine-protease inhibitor PAI-1.
Background References
Trademarks and Patents
Limited Uses
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