Revision 1

#38461Store at -20C

1 Kit

(8 x 20 microliters)

Cell Signaling Technology

Orders: 877-616-CELL (2355) [email protected]

Support: 877-678-TECH (8324)

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3 Trask LaneDanversMassachusetts01923USA
For Research Use Only. Not for Use in Diagnostic Procedures.
Product Includes Product # Quantity Mol. Wt Isotype/Source
IL-1β (D3U3E) Rabbit mAb 12703 20 µl 17, 31 kDa Rabbit IgG
CCL5/RANTES (R40) Antibody 2987 20 µl 10 kDa Rabbit 
CXCL10 (D5L5L) Rabbit mAb 14969 20 µl 10 kDa Rabbit IgG
PAI-1 (D9C4) Rabbit mAb 11907 20 µl 48 kDa Rabbit IgG
IL-6 (D3K2N) Rabbit mAb 12153 20 µl 21-28 kDa Rabbit IgG
TNF-α (D5G9) Rabbit mAb 6945 20 µl 18, 25 kDa Rabbit IgG
MMP-3 (D7F5B) Rabbit mAb 14351 20 µl 60 kDa Rabbit IgG
MCP-1 Antibody (Carboxy-terminal Antigen) 39091 20 µl 13-15 kDa Rabbit 
Anti-rabbit IgG, HRP-linked Antibody 7074 100 µl Goat 

Please visit for individual component applications, species cross-reactivity, dilutions, protocols, and additional product information.


Senescence Associated Secretory Phenotype (SASP) Antibody Sampler Kit provides an economical means of detecting multiple components of the SASP. The kit includes enough antibody to perform two western blot experiments with each primary antibody.


Senescence is characterized by stable stress-induced proliferative arrest and resistance to mitogenic stimuli, as well as the secretion of proteins such as cytokines, growth factors and proteases. These secreted proteins comprise the senescence-associated secretory phenotype (SASP). Senescent cells are thought to accumulate as an organism ages, and contribute to age-related diseases, including cancer, through promotion of inflammation and disruption of normal cellular function (1,2). The composition of the SASP varies, and SASP components can be either beneficial or deleterious in human disease, depending on the context (3).
Senescence Associated Secretory Phenotype (SASP) Antibody Sampler Kit provides a collection of antibodies to various SASP components, including TNF-alpha, interleukin-6 (IL-6), the multifunctional cytokine IL-1beta, the chemokines CXCL10, RANTES/CCL5 and MCP-1, the matrix metalloprotease MMP3, and the serine-protease inhibitor PAI-1.

  1. Tchkonia, T. et al. (2013) J Clin Invest 123, 966-72.
  2. Sun, Y. et al. (2018) Trends Mol Med 24, 871-885.
  3. Rao, S.G. and Jackson, J.G. (2016) Trends Cancer 2, 676-687.

Background References

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