| Product Includes | Product # | Quantity | Mol. Wt | Isotype/Source |
|---|---|---|---|---|
| APP Antibody | 2452 | 20 µl | 100 to 140 kDa | Rabbit |
| β-Amyloid (1-42) (D3E10) Rabbit mAb | 12843 | 20 µl | 4 kDa | Rabbit |
| β-Amyloid (1-40) (D8Q7I) Rabbit mAb | 12990 | 20 µl | 4 kDa | Rabbit IgG |
| β-Amyloid (1-37) (D2A6H) Rabbit mAb | 12467 | 20 µl | 4 kDa | Rabbit IgG |
| β-Amyloid (1-39) (D5Y9L) Rabbit mAb | 12077 | 20 µl | 4 kDa | Rabbit IgG |
| β-Amyloid (D54D2) XP® Rabbit mAb | 8243 | 20 µl | 5 kDa | Rabbit IgG |
| β-Amyloid (pE3 Peptide) (D5N5H) Rabbit mAb | 14975 | 20 µl | 4 kDa | Rabbit IgG |
| Anti-rabbit IgG, HRP-linked Antibody | 7074 | 100 µl | Goat |
Please visit cellsignal.com for individual component applications, species cross-reactivity, dilutions, protocols, and additional product information.
Description
The β-Amyloid Antibody Sampler Kit provides an economical means of detecting APP and APP unmodified/modified fragments using total and fragment-specific antibodies. The kit includes enough antibody to perform two western blot experiments with each primary antibody.
Storage
Background
Amyloid β (Aβ) precursor protein (APP) is a 100-140 kDa transmembrane glycoprotein that exists as several isoforms (1). The amino acid sequence of APP contains an amyloid domain, which can be processed and released by two-step proteolytic cleavage (1). The extracellular deposition and accumulation of the released Aβ fragments form the main components of amyloid plaques in Alzheimer's disease (1). Several fragments corresponding to progressive APP processing at alternative cleavage sites have been identified (2). These include Aβ (1-37), Aβ (1-39), Aβ (1-40), and Aβ (1-42) (2). These fragments can also be N-terminally modified to generate pyroglutamate-3 Aβ (pE3-peptide) (3). Fragment-specific and pan-Aβ antibodies are used to detect and examine relative levels of individual Aβ fragments.
Background References
Trademarks and Patents
Limited Uses
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