Background
Losartan (potassium salt) is a known angiotensin II receptor antagonist by selectively and competitively blocking the binding of the angiotensin II hormone (1). In clinical settings, it is useful as an antihypertensive agent and also displays neuroprotective effects against chronic fatigue stress (2,3). Losartan (potassium salt) inhibits collagen I synthesis and induces sirtuin 1 (SirT1) expression and activity (4,5).
- Chiu, A.T. et al. (1990) J Pharmacol Exp Ther 252, 711-8.
- McIntyre, M. et al. (1997) Pharmacol Ther 74, 181-94.
- Kumar, A. et al. (2015) Inflammopharmacology 23, 291-305.
- Diop-Frimpong, B. et al. (2011) Proc Natl Acad Sci U S A 108, 2909-14.
- Pantazi, E. et al. (2015) World J Gastroenterol 21, 8021-31.
Molecular Formula
C22H22ClN6O • K
Molecular Weight
461 g/mol
Purity
>99%
CAS
124750-99-8
Solubility
Soluble in DMSO at 45 mg/ml or water at 45 mg/ml.
Storage
Directions for Use
Losartan (potassium salt) is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.08 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
Background References
Cross-Reactivity Key
H: human M: mouse R: rat Hm: hamster Mk: monkey Vir: virus Mi: mink C: chicken Dm: D. melanogaster X: Xenopus Z: zebrafish B: bovine Dg: dog Pg: pig Sc: S. cerevisiae Ce: C. elegans Hr: horse GP: Guinea Pig Rab: rabbit All: all species expected
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