IF-IC
H
Endogenous
Rabbit IgG
#P13995
10797
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Immunofluorescence (Immunocytochemistry) | 1:50 |
Storage
Specificity / Sensitivity
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu340 of human MTHFD2 protein.
Product Description
Background
MTHFD2 is a bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase involved in mitochondrial folate metabolism (1). MTHFD2 expression is developmentally regulated, as it is expressed in embryos but not in most adult tissues. Recent research studies have shown that MTHFD2 is consistently overexpressed in many cancer types and correlated with poor survival in breast cancer (2-5). Overexpression of MTHFD2 promotes cell proliferation while its depletion induces cell death in human cancer cells (6).
- Christensen, K.E. and Mackenzie, R.E. (2008) Vitam Horm 79, 393-410.
- Lehtinen, L. et al. (2013) Oncotarget 4, 48-63.
- Nilsson, R. et al. (2014) Nat Commun 5, 3128.
- Liu, F. et al. (2014) Tumour Biol 35, 8685-90.
- Tedeschi, P.M. et al. (2015) Mol Cancer Res 13, 1361-6.
- Gustafsson Sheppard, N. et al. (2015) Sci Rep 5, 15029.
Species Reactivity
Species reactivity is determined by testing in at least one approved application (e.g., western blot).
Applications Key
IF-IC: Immunofluorescence (Immunocytochemistry)
Cross-Reactivity Key
H: human M: mouse R: rat Hm: hamster Mk: monkey Vir: virus Mi: mink C: chicken Dm: D. melanogaster X: Xenopus Z: zebrafish B: bovine Dg: dog Pg: pig Sc: S. cerevisiae Ce: C. elegans Hr: horse GP: Guinea Pig Rab: rabbit All: all species expected
Trademarks and Patents
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