22.3
#P01241
2688
Background
Growth hormone (GH) is a key growth factor secreted by the anterior pituitary gland that binds to the growth hormone receptor (GHR), which is present in many cell types, to exert its biological effects (1,2). GH primarily acts on the liver to stimulate the production and release of IGF-1 which targets metabolism, growth, and differentiation of cartilage, muscle, and bone (2,3). GH can act on differing cell types, muscle, and other tissues to promote lipolysis and increase protein synthesis, calcium retention, and amino acid uptake (4-6). GH deficiencies in children can result in growth failure, short stature, and delayed sexual maturity (7).
- Goffin, V. et al. (1996) Endocr Rev 17, 385-410.
- Le Roith, D. et al. (2001) Endocr Rev 22, 53-74.
- Doessing, S. et al. (2010) J Physiol 588, 341-51.
- Ahmad, A.M. et al. (2003) J Clin Endocrinol Metab 88, 2860-8.
- Caputo, M. et al. (2021) Cells 10, 1376. doi: 10.3390/cells10061376.
- Møller, N. and Jørgensen, J.O. (2009) Endocr Rev 30, 152-77.
- Murrary, P. et al. (2000) Endotext.
Endotoxin
Endotoxin levels are less than or equal to 1 EU / 1 μg hGH.
Purity
A greater than or equal to 95% purity was determined by SDS-PAGE.
Source / Purification
Recombinant human Growth Hormone was expressed in E. coli and is supplied in a lyophilized form.
Background
Growth hormone (GH) is a key growth factor secreted by the anterior pituitary gland that binds to the growth hormone receptor (GHR), which is present in many cell types, to exert its biological effects (1,2). GH primarily acts on the liver to stimulate the production and release of IGF-1 which targets metabolism, growth, and differentiation of cartilage, muscle, and bone (2,3). GH can act on differing cell types, muscle, and other tissues to promote lipolysis and increase protein synthesis, calcium retention, and amino acid uptake (4-6). GH deficiencies in children can result in growth failure, short stature, and delayed sexual maturity (7).
Background References
Cross-Reactivity Key
H: human M: mouse R: rat Hm: hamster Mk: monkey Vir: virus Mi: mink C: chicken Dm: D. melanogaster X: Xenopus Z: zebrafish B: bovine Dg: dog Pg: pig Sc: S. cerevisiae Ce: C. elegans Hr: horse GP: Guinea Pig Rab: rabbit All: all species expected
Trademarks and Patents
Limited Uses
Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.
Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.
