FC-L
H
Endogenous
Rabbit IgG
#P49238
1524
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Flow Cytometry (Live) | 1:50 - 1:200 |
Storage
Specificity / Sensitivity
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human CX3CR1 protein.
Background
CX3C chemokine receptor 1 (CX3CR1) is a member of the seven-transmembrane G-protein coupled receptor (GPCR) family. It is a receptor for its sole ligand, CX3CL1, also known as fractalkine or neurotactin (1). Immune cells that express CX3CR1 include monocytes, macrophages, microglia, T helper (Th) 1 cells, CD8+ T effector/memory cells, NK cells, γδ T cells, and dendritic cells (DCs) (1,2). CX3CR1 has been implicated in inflammatory diseases, such as nephropathy and macular degeneration, and HIV co-receptors. It is emerging as an important player in the regulation of insulin secretion and beta cell function (3). In the brain, CX3CR1 expression is microglia-specific and regulates microglial recruitment to sites of neuroinflammation (1,2). Disruption of CX3CL1-CX3CR1 signaling promotes neurodegeneration in mouse models of Parkinson’s disease and amyotrophic lateral sclerosis but might be protective in Alzheimer’s disease (AD) (2,4,5).
Species Reactivity
Species reactivity is determined by testing in at least one approved application (e.g., western blot).
Applications Key
FC-L: Flow Cytometry (Live)
Cross-Reactivity Key
H: human M: mouse R: rat Hm: hamster Mk: monkey Vir: virus Mi: mink C: chicken Dm: D. melanogaster X: Xenopus Z: zebrafish B: bovine Dg: dog Pg: pig Sc: S. cerevisiae Ce: C. elegans Hr: horse GP: Guinea Pig Rab: rabbit All: all species expected
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