| Product Includes | Product # | Quantity | Mol. Wt | Isotype/Source |
|---|---|---|---|---|
| FANCA (D1L2Z) Rabbit mAb | 14657 | 20 µl | 160 kDa | Rabbit IgG |
| FANCB (D9W6S) Rabbit mAb | 14243 | 20 µl | 90 kDa | Rabbit IgG |
| FANCD2 (D5L5X) Rabbit mAb | 16323 | 20 µl | 155, 162 kDa | Rabbit IgG |
| BRCA2 (D9S6V) Rabbit mAb | 10741 | 20 µl | 380 kDa | Rabbit IgG |
| BRIP1/FANCJ Antibody | 4578 | 20 µl | 145 kDa | Rabbit |
| Anti-rabbit IgG, HRP-linked Antibody | 7074 | 100 µl | Goat |
Please visit cellsignal.com for individual component applications, species cross-reactivity, dilutions, protocols, and additional product information.
Description
The Fanconi Anemia Antibody Sampler Kit provides an economical means of detecting members of the Fanconi Anemia signaling pathway. The kit includes enough antibody to perform two western blot experiments with each primary antibody.
Storage
Background
Fanconi anemia (FA) is an autosomal recessive genetic disorder resulting in symptoms that include chromosomal breakage, bone marrow failure, hypersensitivity to DNA cross-linking agents (such as mitomycin C), and a predisposition to cancer (1). In response to DNA damage, the FA nuclear complex (FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCM) induces mono-ubiquitination of FANCD2 and FANCI (2).Monoubiquitination of FANCD2 induces localization of FANCD2 to sites of DNA damage, where it interacts with BRCA1. FANCJ/BRIP1, FANCD1/BRCA2, and FANCN/PALB2 are also recruited to sites of DNA damage (3).
Background References
Trademarks and Patents
Limited Uses
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