| Product Includes | Product # | Quantity | Mol. Wt | Isotype/Source |
|---|---|---|---|---|
| GSK-3α (D80E6) Rabbit mAb | 4337 | 20 µl | 51 kDa | Rabbit IgG |
| Phospho-GSK-3α (Ser21) (36E9) Rabbit mAb | 9316 | 20 µl | 51 kDa | Rabbit |
| Phospho-GSK-3β (Ser9) (D85E12) XP® Rabbit mAb | 5558 | 20 µl | 46 kDa | Rabbit IgG |
| Phospho-GSK-3α/β (Ser21/9) (D17D2) Rabbit mAb | 8566 | 20 µl | 46 GSK-3beta, 51 GSK-3alpha kDa | Rabbit IgG |
| GSK-3β (D5C5Z) XP® Rabbit mAb | 12456 | 20 µl | 46 kDa | Rabbit IgG |
| Anti-rabbit IgG, HRP-linked Antibody | 7074 | 100 µl | Goat |
Please visit cellsignal.com for individual component applications, species cross-reactivity, dilutions, protocols, and additional product information.
Description
The GSK-3 Antibody Sampler Kit contains primary and secondary antibodies to perform two Western blots with each antibody.
Storage
Background
Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin (1). GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β (2,3). GSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development (4). GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization (5).
Background References
Trademarks and Patents
Limited Uses
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