| Product Includes | Product # | Quantity | Mol. Wt | Isotype/Source |
|---|---|---|---|---|
| Phospho-YAP (Ser397) (D1E7Y) Rabbit mAb | 13619 | 20 µl | 65-78 kDa | Rabbit IgG |
| LATS1 (C66B5) Rabbit mAb | 3477 | 20 µl | 140 kDa | Rabbit IgG |
| Phospho-MOB1 (Thr35) (D2F10) Rabbit mAb | 8699 | 20 µl | 24 kDa | Rabbit IgG |
| MOB1 (E1N9D) Rabbit mAb | 13730 | 20 µl | 24 kDa | Rabbit IgG |
| MST1 Antibody | 3682 | 20 µl | 59 kDa | Rabbit |
| MST2 Antibody | 3952 | 20 µl | 60 kDa | Rabbit |
| SAV1 (D6M6X) Rabbit mAb | 13301 | 20 µl | 45 kDa | Rabbit IgG |
| Phospho-YAP (Ser127) (D9W2I) Rabbit mAb | 13008 | 20 µl | 65-78 kDa | Rabbit IgG |
| YAP/TAZ (D24E4) Rabbit mAb | 8418 | 20 µl | 55, 78 kDa | Rabbit IgG |
| Anti-rabbit IgG, HRP-linked Antibody | 7074 | 100 µl | Goat |
Please visit cellsignal.com for individual component applications, species cross-reactivity, dilutions, protocols, and additional product information.
Description
The Hippo Signaling Antibody Sampler Kit provides an economical means of detecting target proteins of the Hippo signaling pathway. The kit contains enough primary antibody to perform two western blots per primary.
Storage
Background
Hippo signaling is an evolutionarily conserved pathway that controls cell proliferation, apoptosis, and organ size in response to changing cell density levels (1,2). At relative low cell density, transcription co-activators YAP and TAZ bind transcription factors to induce expression of genes that favor cell growth and proliferation. As cell density increases, interaction between membrane-bound upstream hippo pathway regulators trigger activation of cytoplasmic kinases Mst1/2 and LATS1/2. Activated Mst kinase (the eponymous Hippo in Drosophila) associates with the adaptor Sav1 and phosphorylates MOB1 to activate LATS kinase, which phosphorylates YAP and TAZ to suppress cell proliferation (3).
Background References
Trademarks and Patents
Limited Uses
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